l-histidine s-malate

L-Histidine S-malate is a bioactive chemical.

S-Adenosyl-L-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the disulfate-tosylate mixed salt comprising diastereoisomers of ademetionine ions. Ademetionine exhibits anti-inflammatory properties and has been utilized in the treatment of chronic liver disease.

L-(R,S)-Tetrahydropalmatine (Rotundine) is extracted from Corydalis yanhusuo W. T. Wang.

L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect nerve cells and is metabolized to the neurotransmitter histamine. Histamines play many roles in immunity, gastric secretion, and sexual functions. L-Histidine is also required for blood cell manufacture and protects tissues against damage caused by radiation and heavy metals.

L-Histidine benzyl ester bistosylate may serve as an activator for HutP, an RNA-binding protein.

S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective for Eg5 over nine other human kinesins in an enzyme-coupled assay. It reversibly inhibits Eg5-driven microtubule sliding velocity with an IC50 value of 500 nM using X. laevis recombinant Eg5. It induces cell cycle arrest in HeLa cells (IC50 = 700 nM), reversibly halting the cell cycle in the mitotic phase by inhibiting the separation of duplicated chromosomes and preventing bipolar spindle formation. S-trityl-L-Cysteine inhibits the growth of cancer cells in vitro when tested against the National Cancer Institute (NCI) 60 human cancer cell line panel (average GI50 = 1.3 μM) and in mouse xenograft models.

S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.

Cabozantinib S-malate (XL184) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity.

Histidine (abbreviated as His or H) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a charged, polar because of the hydrophilic nature of the imidazole side chain.

L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase [1].

S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.

S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases [1]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use [2]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity [3].

S-allyl-L-cysteine (S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals.

γ-L-Glutamyl-S-allyl-L-cysteine is an organosulfur compound naturally present in garlic [1].

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) is an anticarcinogenic agent that exhibits antileukemic activity by inhibiting DNA synthesis in HL60 cells [1] and acts as an inhibitor of P450 [2].

Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and invasive effects, it effectively impacts pancreatic cancer BxPC-3 and PANC-1 cells.

S-(3-Carboxypropyl)-L-cysteine is a thioether derivative of L-cysteine.

N-[(S)-1-Carbethoxy-1-butyl]-L-alanine is a useful organic compound for research related to life sciences. The catalog number is T65104 and the CAS number is 82834-12-6.

S-Adenosyl-L-methionine tosylate is a useful organic compound for research related to life sciences and the catalog number is T124334.

S-Adenosyl-L-Methionine iodide salt is a useful organic compound for research related to life sciences and the catalog number is T124985.

HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a peptide-cleavable agent-linker conjugate used in antibody-drug conjugates (ADCs), with DM indicating the maytansinoid component [1].

S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agent. This compound is generated from sulforaphane through intermediates - DL-sulforaphane glutathione and sulforaphane cysteinylglycine - via the mercapturic acid pathway enzymes. At a concentration of 20 µM, SFN-Cys diminishes invasion and migration of U87MG and U373 MG glioblastoma cells as observed in wound healing and chamber assays. Furthermore, at 45 µM, it significantly lowers the expression of α-tubulin, βIII-tubulin, stathmin 1, and X-linked inhibitor of apoptosis (XIAP), and also reduces cell density in paclitaxel-resistant A549 lung cancer cells (A549/T). Additionally, when used at 30 µM, SFN-Cys prompts apoptosis and cell cycle arrest at the G2/M phase in U87MG and U373 MG cells.

N-Acetyl-L-histidine monohydrate is a natural product for research related to life sciences. The catalog number is T38094 and the CAS number is 39145-52-3.

L-Cysteine S-sulfate sodium salt sesquihydrate is a useful organic compound for research related to life sciences. The catalog number is T64782 and the CAS number is 150465-29-5.

L-Lysine (S)-maleate is used in the preparation of amino acid ionic liquids in the food and medical field.

2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate is a useful organic compound for research related to life sciences. The catalog number is T64609 and the CAS number is 1911578-98-7.

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-benzyl-L-cysteine, catalog number T67626 and CAS number 53298-33-2, is a valuable organic compound for life sciences research.

somatostatin sst2 receptor agonist

S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is an essential methyl donor found in all living organisms [1].

L-Buthionine-(S,R)-sulfoximine, a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), induces oxidative stress in cells by depleting GSH.

N-Cbz-L-histidine is a useful organic compound for research related to life sciences and the catalog number is T65767.

S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-proliferative, pro-apoptotic, and anti-metastatic roles in cancer. SAMe 1,4-butanedisulfonate holds promise in research pertaining to cancer, liver disease, and osteoarthritis [1] [2] [3].

Fmoc-1-methyl-L-histidine is a valuable organic compound for life sciences research (Catalog No.: T66680, CAS: 202920-22-7).

L-Cystine S,S-dioxide is a metabolite of L-Cystine.

L-Buthionine-(S,R)-sulfoximine hydrochloride is a potent, cell-permeable, fast-acting, irreversible inhibitor of G-glutamylcysteine synthetase (γ-GCS) that depletes cellular glutathione levels. It has IC50s of 1.9 μM, 8.6 μM, and 29 μM in melanoma, breast, and ovarian tumor specimens, respectively [1] [2].

Compound 40, NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal), a macrocyclic analogue of Ape13, acts as a potent APJ agonist with a Ki of 5.7 nM. It demonstrates favorable Gα12-biased signaling and possesses an enhanced in vivo half-life [1].

Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.

S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases survival in a mouse model of HSV-1 infection.

L-Deoxyalliin , also known as S-allyl-L-cysteine, is a water soluble organosulfur compound derived from garlic that has neuroprotective and antioxidative activities. N-Acetyl-S-allyl-L-cysteine is a principal metabolite of L-deoxyalliin in humans, mice, rats, and dogs. It is readily detected in plasma and urine. The conversion of L-deoxyalliin to N-acetyl-S-allyl-L-cysteine appears to be mediated by a family of flavin-containing monooxygenases.

S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensive animal models.

S-(Acetamidomethyl)-N-(tert-butoxycarbonyl)-L-cysteine, catalog number T65253 and CAS number 19746-37-3, is a valuable organic compound for life sciences research.

N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

N-Formyl-L-histidine demonstrates a binding affinity for histidyl-tRNA synthetase, featuring a K i value of 4.6 μM. Additionally, it acts as a competitive inhibitor against L-histidine ammonia-lyase, suppressing urocanic acid formation from L-histidine with a K i value of 4.26 mM [1] [2].

S-Geranylgeranyl-L-glutathione acts as a ligand for the orphan G protein-coupled receptor (GPCR) P2RY8, displaying selective affinity by inducing internalization of P2RY8 in preference to the sphingosine-1-phosphate receptor 2 (S1P2), GPR55, cysteinyl leukotriene receptor 1 (CysLT1 receptor), and the CysLT2 receptor at a concentration of 100 nM. Additionally, at a lower concentration of 10 nM, S-Geranylgeranyl-L-glutathione inhibits the chemokine (C-X-C motif) ligand 12-induced migration of both P2RY8-expressing WEHI-231 B cell lymphoma cells and human tonsil germinal center B cells.

S-(5'-Adenosyl)-L-methionine chloride is a natural product. The catalog number is TN6669 and the CAS number is 24346-00-7. S-(5'-Adenosyl)-L-methionine chloride can be used as a reference standard.

S-Methyl-L-cysteine (S-Methylcysteine) is a natural product serving as a substrate in the methionine sulfoxide reductase A (MSRA) catalyzed antioxidant system, exhibiting neuroprotective, antioxidative, and anti-obesity properties.

S-(2-Carboxyethyl)-L-cysteine (S-Carboxyethylcysteine), a modified sulfur amino acid found in Acacia seeds, influences protein utilization and suppresses methionine-induced growth rates in rats, while adversely affecting plasma amino acid concentrations in these animals [1].

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(tert-butylthio)-L-cysteine (catalog number: T66172, CAS: 73724-43-3) is a valuable organic compound utilized in life sciences research.