n-methyl-n'-(azide-peg-3)-cy3

N-methyl-N'-(azide-PEG3)-Cy3 is a PEG-based linker compound intended for the synthesis of PROTACs [1].

AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].

N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride, a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1) programmed cell death ligand 1 (PD-L1) inhibitor, inhibits the PD-1 PD-L1 interaction with an IC50 of 39.2 nM. It contains the target protein PD-1 PD-L1 ligand and PROTAC linker, which can be used to synthesize PROTAC PD-1 PD-L1 degrader-1 and has anticancer activity. Additionally, it serves as a diluent for the preparation of tablets for direct compression.

Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.

Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].

N-Boc-PEG5-bromide is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and serves as a PROTAC linker based on PEG and Alkyl ether.

Fmoc-N-amido-PEG2-alcohol is a PEG-based linker for PROTACs [which joins two essential ligands], crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

3-Mercaptopropionic acid NHS ester is a useful organic compound for research related to life sciences and the catalog number is T64663.

LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the CDK9 inhibitor, SNS 032, linked to a hydrophobic tag via a glycol linker. Notably, LL-K9-3 does not affect the degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). Tested in 22RV1 cells, it effectively reduces androgen receptor (AR) and cMyc expression by inducing the selective and synchronous degradation of CDK9 and cyclin T1.

Methyl 3-hydroxypropanoate is a PROTAC linker compound, which belongs to the alkyl ether family. It is commonly employed in the synthesis of PROTACs.

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a polyethylene glycol-based PROTAC linker used in the synthesis of PROTACs.

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule designed for synthesizing proteolysis-targeting chimeras (PROTACs).

PROTAC EGFR Degrader 3, a highly potent molecule, exhibits remarkable cellular activity against H1975 and HCC827 cells, maintaining high selectivity. It additionally reveals the lysosome's crucial role in the degradation mechanism of mutant EGFR [1].

m-PEG2-O-Ph-3-NH2 is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1/PD-L1 degrader-1, which facilitates the degradation of PD-1/PD-L1. BMS-1166 demonstrates potent inhibition of PD-1/PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1/PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation.

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).

OICR-9429-N-C2-NH2, a ligand for WDR5, intermediate 2, serves as a crucial compound in the synthesis of PROTACs.

N-(Azido-PEG3)-NH-PEG3-acid is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

THP-PEG4-Pyrrolidine(N-Me)-CH2OH, a PEG-based PROTAC linker, aids in the synthesis of PROTAC K-Ras Degrader-1[1].

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker incorporating biotin for labeling, making it a versatile tool in PROTAC synthesis[1].

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based linker compound employed in PROTAC synthesis [1].

N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a polyethylene glycol (PEG)-based PROTAC linker used for synthesizing PROTACs[1].

N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a polyethylene glycol (PEG) derivative utilized as a PROTAC linker for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].

N-(Azido-PEG3)-N-Boc-PEG4-Boc is a polyethylene glycol (PEG)-based proteolysis targeting chimeric (PROTAC) linker used in PROTAC synthesis[1].

N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-derived linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-(Amino-PEG3)-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-(m-PEG9)-N'-(propargyl-PEG8)-Cy5 is a polyethylene glycol (PEG)-based PROTAC linker designed for synthesizing PROTACs [1].

N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group, primarily used in PROTAC synthesis [1].

N-(m-PEG4)-N'-(PEG4-NHS ester)-Cy5 is a polyethylene glycol (PEG)-based linker frequently used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker, assisting in the synthesis of PROTACs[1].

N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker used in PROTAC synthesis [1].

N-Mal-N-bis(PEG2-NH-Boc) is a polyethylene glycol (PEG) derived linker designed for synthesizing proteolysis targeting chimeras (PROTACs)[1].

N-Boc-PEG5-alcohol is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the selective protein degradation through the ubiquitin-proteasome system within cells.

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker suitable for synthesizing PROTACs [1].

Fmoc-N-PEG24-acid is a PEG-based linker for PROTACs, crucial for connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

N-Mal-N-bis(PEG2-amine) is a polyethylene glycol (PEG)-based linker compound commonly used in the construction of PROTACs, or proteolysis-targeting chimeras[1].

Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) linker compound, designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1].

N-Boc-N-bis(PEG2-OH) is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

N-(Propanoic acid)-N-bis(m-PEG12) is a polyethylene glycol (PEG) based linker used in PROTACs synthesis [1].

N-Boc-PEG16-alcohol is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Hydroxypropyl-N’-(azide-PEG3)-Cy3 is a polyethylene glycol (PEG)-based linker, specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs) [1].

Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derivative of Estrone that specifically binds to estrogen receptor α (ERα). With a linker, it complexes with the cIAP1 ligand Bestatin, forming SNIPER[1].

N-DBCO-N-bis(PEG2-C2-acid) is a polyethylene glycol (PEG) linker commonly employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].