pf-17

PF-17 can be used as a PUF60 inhibitor for the treatment of ovarian cancer.

PF-4981517 (CYP3cide) is a efficient, specific and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC 50 values for CYP3A activity are 0.03 μM,17 μM, and 71 μM for CYP3A4, CYP3A5, and CYP3A7, respectively. PF-4981517 is able to be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug Metabolism.

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM [1].

PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.

Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).

Brepocitinib (PF-06700841) is a potent dual JAK1 TYK2 inhibitor with IC50 values of 17 nM and 23 nM, respectively, and also inhibits JAK2 and JAK3 with IC50 values of 77 nM and 6.49 μM.

PF-719 is a potent, selective Pyk2 inhibitor with IC50 of 17 nM.

Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).