Phenelzine is an antidepressant and mania drug, which is a monoamine oxidase inhibitor. Its antidepressant effect is similar to that of niacinamide. It can reduce the degradation of catecholamines (norepinephrine, dopamine, and serotonin) in the brain and increase the content of catecholamines. , and play an antidepressant effect. It has a good effect on endogenous depression but has a poor effect on exogenous and reactive depression.

Phenelzine sulfate is a non-selective and irreversible inhibitor of monoamine oxidase (MAOI), and with antidepressant and anxiolytic.

H77-77, a monoamine oxidase (MAO) inhibitor, produces a pronounced protection against phenelzine within the serotonergic and noradrenergic neurons in rats.

Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>K i of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine has potential applications in neuroprotective [1].