ret v804m in 1

RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).

pGlu-K(-NBD)-Q-R-L-G-N-Q-W-A-V-G-H-L-M-N is a peptides

Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.

β2AR/M-receptor agonist-1 (example 131), a muscarinic antagonist and β2 adrenoceptor agonist (MABA), exhibits dual potency towards β2 adrenoceptor and muscarinic receptor. It demonstrates a significant affinity for the β2 adrenoceptor, indicated by an EC50 value of 9.2 nM, and for the muscarinic receptor with a Ki value of 30.2 nM. Furthermore, its MABA activity is highlighted by an EC50 value of 4.0 nM [1].

RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).

1,3-Butanediol, 1-(m-chlorophenyl)-4,4,4-trifluoro-3-trifluoromethyl- is a bioactive chemical.

Phenol, m-(1-methyl-3-propyl-3-pyrrolidinyl)-, butyrate is a bioactive chemical.

1-(b-D-Xylofuranosyl)-N6-(m-trifluoromethyl benzyl) adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside, Fluoro-modified nucleoside.

m-(1-Methylbutyl)phenyl methylcarbamate is a bioactive chemical.

Benzoic acid, m-(2-(p-bromophenyl)-5-methylpyrrol-1-yl)- is a bioactive chemical.

m-Dioxane, 5-isopropyl-5-(1-methoxyethyl)-2-methyl-, (E)- is a bioactive chemical.

Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)-, compd. with 2-amino-2-methyl-1-propanol (1:1) is a bioactive chemical.

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(1-methyl-2-piperidino)ethyl- is a bioactive chemical.

Lopinavir Metabolite M-1, an active metabolite derived from Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM. Additionally, in vitro studies have revealed notable antiviral properties associated with Lopinavir Metabolite M-1.

Phenol, m-(1-methyl-3-propyl-3-pyrrolidinyl)-, acetate is a bioactive chemical.

Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)- is a bioactive chemical.

Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)-, compd. with 2-aminoethanol (1:1) is a bioactive chemical.

Phenol, m-(2,3-dipropyl-1-methyl-3-pyrrolidinyl)- is a bioactive chemical.

m-Anisidine, 4-((1-methylheptyl)oxy)-, hydrochloride is a bioactive chemical.

V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) is a precursor compound of cholecystokinin (CCK). Cholecystokinin (CCK) is a brain-intestinal peptide that stimulates gallbladder contraction and pancreatic exocrine. It can be extracted from the small intestine of dogs and cats and can cause gallbladder contraction.

Phenol, m-(2,3-dipropyl-1-methyl-3-pyrrolidinyl)-, acetate is a bioactive chemical.

m-(1-Pyrrolidinyl)phenol is a bioactive chemical.

Carbanilic acid, m-((hexyloxy)methyl)-, 2-(hexahydro-1H-azepin-1-yl)ethyl ester, hydrochloride is a bioactive chemical.

Phenol, m-(2-ethyl-1-methyl-3-propyl-3-pyrrolidinyl)-, acetate is a bioactive chemical.

4,4,4-Trifluoro-1-(m-tolyl)butane-1,3-dione is a useful organic compound for research related to life sciences. The catalog number is T66381 and the CAS number is 53764-99-1.

Phenol, m-(2-(N-ethylphenethylamino)ethyl)-, fumarate (1:1) is a bioactive chemical.

Phenol, m-(2-ethyl-1-methyl-3-propyl-3-pyrrolidinyl)- is a bioactive chemical.

m-((4-((4-(Bis(2-hydroxyethyl)amino)phenyl)azo)-1-naphthyl)azo)benzenesulphonic acid is a bioactive chemical.

Phenol, m-(1-methyl-3-neopentyl-3-pyrrolidinyl)- is a bioactive chemical.

Carbanilic acid, m-((pentyloxy)methyl)-, 2-(1-pyrrolidinyl)ethyl ester, hydrochloride is a bioactive chemical.

Benzoic acid, m-(1-phenylureido)- is a bioactive chemical.

Phenol, m-(1-methyl-3-(2-methylbutyl)-3-pyrrolidinyl)- is a bioactive chemical.

Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)-, compd. with morpholine (1:1) is a bioactive chemical.

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(2-(1-pyrrolidinyl)ethyl)-, hydrochloride is a bioactive chemical.

Carbanilic acid, m-((pentyloxy)methyl)-, 2-(hexahydro-1H-azepin-1-yl)ethyl ester, hydrochloride is a bioactive chemical.

1-(b-D-Xylofuranosyl)-N6-(m-methoxybenzyl) adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside.

Phenol, m-(1-methyl-3-propionyl-3-pyrrolidinyl)-, hydrochloride is a bioactive chemical.

Phenol, m-(1-(p-hydroxyphenethyl)-3-isopropyl-3-pyrrolidinyl)-, hydrochloride, hydrate is a bioactive chemical.

Carbanilic acid, m-((hexyloxy)methyl)-, 2-(1-pyrrolidinyl)ethyl ester, hydrochloride is a bioactive chemical.

Benzoic acid, m-(2,5-dimethylpyrrol-1-yl)- is a bioactive chemical.

1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine , Clofarabine , Fludarabine phosphate and Vidarabine [1] .

1-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine , Clofarabine , Fludarabine phosphate and Vidarabine [1] .

1-(m-Tolyl)ethanone is a useful organic compound for research related to life sciences. The catalog number is T66804 and the CAS number is 585-74-0.

Phenol, m-(2-(dimethylaminomethyl)-1-hydroxycyclopentyl)- is a bioactive chemical.

N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 is a polyethylene glycol (PEG)-based linker compound primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Phenol, m-(1-allyl-2,3-dimethyl-3-piperidyl)-, hydrobromide is a bioactive chemical.

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(1-methyl-2-(1-pyrrolidinyl)ethyl)-, hydrochloride is a bioactive chemical.

Phenol, m-(1-methyl-3-propyl-3-pyrrolidinyl)-, isobutyrate is a bioactive chemical.

Benzoic acid, m-(2,5-dimethylpyrrol-1-yl)-, hydrazide is a bioactive chemical.

RET-IN-23 (compound 17) is a potent, orally active inhibitor of RET, displaying IC50 values of 1.32 nM for RET-WT, 2.50 nM for RET-CCDC6, 6.54 nM for RET-V804L, 1.03 nM for RET-V804M, and 1.47 nM for RET-M918T. The compound demonstrates significant anti-tumor activity [1].