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MAPK MLK

MLK

Mixed-lineage kinases (MLKs) are serine/threonine-directed protein kinases. MLKs are members of mitogen-activated-protein kinase (MAPK) modules that contain c-Jun amino-terminal kinase (JNKs) or p38 MAPKs.
Cat No. product name
T2048 LY-364947 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T2696 PRT062607 hydrochlorideHOT PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
T6104 Cerdulatinib hydrochloride Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and ...
T6904 Necrosulfonamide Necrosulfonamide is a selective and effective necrosis inhibitor and blocks the MLKL.
T7129 Necrosulfonamide Necrosulfonamide is a novel inhibitor of MLKL.
T13564 AZ7550 AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T13564L AZ7550 hydrochloride AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T13564L2 AZ7550 Mesylate AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
LY-364947
T2048CAS 396129-53-6
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
PRT062607 hydrochloride HOT
T2696CAS 1370261-97-4
PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
URMC-099
T6057CAS 1229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
Cerdulatinib hydrochloride
T6104CAS 1369761-01-2
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and ...
Necrosulfonamide
T6904CAS 1360614-48-7
Necrosulfonamide is a selective and effective necrosis inhibitor and blocks the MLKL.
Necrosulfonamide
T7129CAS 432531-71-0
Necrosulfonamide is a novel inhibitor of MLKL.
AZ7550
T13564CAS 1421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
AZ7550 hydrochloride
T13564LCAS
AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
AZ7550 Mesylate
T13564L2CAS
AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).