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MLK

Mixed-lineage kinases (MLKs) are serine/threonine-directed protein kinases. MLKs are members of mitogen-activated-protein kinase (MAPK) modules that contain c-Jun amino-terminal kinase (JNKs) or p38 MAPKs.
Cat No. product name
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T2048 LY-364947 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T13564 AZ7550 AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T2696 PRT062607 hydrochloride PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
T7129 Necrosulfonamide Necrosulfonamide is a novel inhibitor of MLKL.
T11520 GW806742X GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity...
T6904 Necrosulfonamide (E)-Necrosulfonamide is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-...
T6104 Cerdulatinib hydrochloride Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
T13564L2 AZ7550 Mesylate (1421373-99-0 free base) AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
LY-364947
T2048
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
PRT062607 hydrochloride
T2696
PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
Necrosulfonamide
T7129
Necrosulfonamide is a novel inhibitor of MLKL.
GW806742X
T11520
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activit...
Necrosulfonamide
T6904
(E)-Necrosulfonamide is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-...
Cerdulatinib hydrochloride
T6104
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
AZ7550 Mesylate (1421373-99-0 free base)
T13564L2
AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).