PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product name	CAS No.	Purity
T2P2806	Hederacolchiside A1	106577-39-3	99.92%
T2P2806	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the paras...
T4398	LX2343	333745-53-2	99.92%
T4398	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
T33467	MOMIPP	1363421-46-8	99.92%
T33467	MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progre...
T2248	AS-605240	648450-29-7	99.91%
T2248	AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).
T15789	LTURM34	1879887-96-3	99.91%
T15789	LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
T15431	Nemiralisib	1254036-71-9	99.91%
T15431	Nemiralisib（GSK-2269557 free base） is an orally available, potent and specific PI3Kδ inhibitor with a pKi of 9.9.Nemiralisib is used for the treatment of respira...
T12310	ON 146040	1404231-34-0	99.89%
T12310	ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
T2667	PIK-75	372196-67-3	99.88%
T2667	PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
T2265	Bimiralisib	1225037-39-7	99.88%
T2265	Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the...
T2619	CH5132799	1007207-67-1	99.87%
T2619	CH5132799 has been used in trials studying the treatment of Solid Tumors.
T2682	Acalisib	870281-34-8	99.87%
T2682	Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.
T11129L	Duvelisib (R enantiomer) hydrochloride		99.87%
T11129L	Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor. Duvelisib (R enantiomer) hydrochloride is the less active enantiomer of Du...
T67845	ARUK2001607		99.86%
T67845	ARUK2001607 is a selective inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ, Kd= 7.1 nM). ARUK2001607 exhibits high selectivity over other >150 ...
T12468	PI4KIIIbeta-IN-10	1881233-39-1	99.85%
T12468	PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).
T14552	Dactolisib Tosylate	1028385-32-1	99.85%
T14552	Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR. dactolisib Tosylate exhibits IC50 values of 4, 75, 7, and 5 nM for P...
T6394	AS-604850	648449-76-7	99.84%
T6394	AS-604850 is a specific and ATP-competitive PI3Kγ inhibitor (IC50: 250 nM), 18-fold more selective for PI3Kγ than PI3Kα, and over 80-fold selectivity for PI3Kγ t...
T3556	NIH-12848	959551-10-1	99.84%
T3556	NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.
T5S0896	Loureirin A	119425-89-7	99.84%
T5S0896	Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced p...
T2616	PIK-93	593960-11-3	99.83%
T2616	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T4976	Umbralisib	1532533-67-7	99.83%
T4976	Umbralisib (TGR 1202) is a PI3Kδ inhibitor.