TOPK

T-LAK cell-originated protein kinase (TOPK) is a MAPKK-like kinase which plays a role in cell cycle regulation and mitotic progression. As a consequence, TOPK expression is minimal in differentiated cells, although its overexpression is a pathophysiological feature of many tumours. Hence, TOPK has garnered interest as a cancer-specific biomarker and biochemical target with the potential to enhance cancer therapy whilst causing minimal harm to normal tissues.

Cat No.	product name
T0199	Cephradine	Cephradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
T4134L	OTS514	OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell l...
T4135	OTS964 hydrochloride	OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity.
T4134	OTS514 hydrochloride(1338540-63-8(free base))	OTS514 is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
T1756	Ilaprazole sodium	Ilaprazole, a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environ...
T15481	HI-TOPK-032	HI-TOPK-032 is an effective and specific inhibitor of TOPK.
T1756L	Ilaprazole	Ilaprazole is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that...

Cat No.

product name

T0199

Cephradine

Cephradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.

T4134L

OTS514

OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell l...

T4135

OTS964 hydrochloride

OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity.

T4134

OTS514 hydrochloride(1338540-63-8(free base))

OTS514 is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).

T1756

Ilaprazole sodium

Ilaprazole, a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environ...

T15481

HI-TOPK-032

HI-TOPK-032 is an effective and specific inhibitor of TOPK.

T1756L

Ilaprazole

Ilaprazole is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that...