()sparteine

(+)-Sparteine ​​is a quinoline alkaloid extracted from Scotch broom, a sodium channel blocker and a class 1a antiarrhythmic agent. It competitively inhibits the activity of nicotinic acetylcholine receptors in nerve cells and is a ganglionic blocking agent.

Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.

Sparteine is a natural product

(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) is a class 1a antiarrhythmic agent and sodium channel blocker capable of chelating bivalent calcium and magnesium.

Sparteine sulfate (Tocosimplex) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.

(-)-Sparteine hydroiodide, a natural alkaloid, can be isolated from beans [1].

(+)-Sparteine (sulfate pentahydrate) is a ganglion blocker that competitively inhibits nicotinic acetylcholine receptors in neurons.

Lupanine hydrochloride, a natural ketonic derivative of Sparteine ((+)-Sparteine), exhibits ganglioplegic activity and binds to the nicotinic receptor (nAChR) with a K i value of 500 nM [1].