[nle11]substance p

[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems. Substance P was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons.

[Tyr8,Nle11] Substance P, an analog of Substance P, is primarily a neuron-secreted peptide participating in diverse biological functions such as nociception and inflammation [1].

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist that effectively inhibits the actions of gold-protein-substance P (GPSP) and substance P (SP), demonstrating its efficacy in neutralizing their effects [1].

[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) is a broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

[D-Trp7,9,10]-Substance P acetate is an analogue of substance P which inhibits ion conductance through nicotinic acetylcholine receptors.

Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

Substance P 1-9 aceate is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.

[Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P acetate is the sole to produce grooming.

Substance P (2-11), a fragment peptide of Substance P (SP), exhibits contractile effects on the guinea pig ileum and inhibits the permeation of tritiated SP (3 H SP) across brain microvessel endothelial cell (BBMEC) monolayers [1] [2].

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate), an antagonist for Substance P and Bombesin, modulates ocular inflammatory responses triggered by antidromic trigeminal nerve stimulation [1].

Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In

[D-Pro2,D-Phe7,D-Trp9] Substance P, an analogue of Substance P, serves as an inhibitor to its parent compound and indirectly contracts the guinea-pig ileum (GPI) [1] [2].

[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent antagonist to Substance P, significantly reducing plasma aldosterone (ALDO) concentrations[1].

Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.

Substance P (3-11), an SP fragment peptide capable of crossing the blood-brain barrier (BBB), induces contraction in guinea pig ileum and facilitates chemotaxis in human monocytes [1] [2] [5].

[D-Pro4,D-Trp7,9,10] Substance P (4-11) serves as a potent antagonist of the tachykinin family of neuropeptides [1].

[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

Substance P(1-4) acts as a potent antagonist of neurokinin receptors (NK-R) and regulates normal hematopoiesis, additionally inhibiting the formation of endogenous erythroid colonies (EEC) [1].

Biotin-Substance P acts as a neurotransmitter and neuromodulator in the central nervous system. Neurokinin 1 receptor (NK1R) is the endogenous receptor of Biotin-Substance P.

Substance P(1-7) TFA, a fragment of the neuropeptide substance P (SP), induces depressor and bradycardic effects upon application to the nucleus tractus solitarius [1].

[Glp5] Substance P (5-11), an octapeptide, serves as a principal fragment of substance P in the rat central nervous system (CNS) and has a localized role in modulating dopamine release in the rat striatum [1].

[D-Pro2,D-Trp7,9] Substance P, an analogue of Substance P, functions both as a weak agonist and as a potent, specific, competitive antagonist to Substance P [1] [2].

Substance P (6-11), the C-terminal hexapeptideamide of Substance P, exhibits affinity for the NK-1 tachykinin receptor, leading to motoneuron depolarization and a hypotensive effect [1] [2].

[Glp5,Sar9] Substance P (5-11) is an analogue of Substance P [1] .

[Sar9,Met(O2)11]-Substance P TFA is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissi

Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS, targeting the neurokinin 1 receptor (NK1-receptor, NK1R).

Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P .

Substance P, Free Acid is a synthetic analog of native Substance P, however, it lacks the biological activity exhibited by Substance P.

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P is a neuropeptide Substance P antagonist [1] .

[DAla4] Substance P (4-11), an analog of Substance P (Substance P), effectively inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin) and 125I-Bolton Hunter-conjugated Substance P to rat brain cortex membranes, with IC50 values of 0.5 μM and 0.15 μM, respectively [1].

Substance P-Gly-Lys-Arg, also referred to as β-Preprotachykinin (58-71), is an analog of Substance P.

Substance P (5-11), the C-terminal heptapeptide derived from Substance P, functions as a neuropeptide. It specifically interacts with the NK-1 tachykinin receptor [1].

[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist that exhibits inhibitory affinities (K_i values) of 1 μM for NK-1, 1.3 μM for NK-2, and approximately 9 μM for NK-3 receptors [1].

Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.

[Sar9,Met(O2)11]-Substance P (NA) is an agonist of NK1 receptor.

Substance P (alligator), a neuropeptide derived from alligator, possesses a primary structure delineated as Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 [1].

Substance P (4-11), a C-terminal fragment of Substance P, acts as a highly selective agonist for NK1 receptors, demonstrating specificity in its interaction.

[Sar4] Substance P (4-11) is a Substance P agonist and an analog of the C-terminus fragment of Substance P, known as Substance P (4-11) [1].

Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder. Subtance P is responsible for a number of excitatory effects on both central and peripheral neurons.

Substance P (1-7)(TFA) is a fragment of the neuropeptide, substance P (SP).

[Pro9]-Substance P is a highly effective, reversible, and selective agonist for NK-1 tachykinin receptors, demonstrating an EC50 value of 0.93 nM [1].

[Glp6] Substance P (6-11) is an analogue of the native peptide, Substance P (6-11), known to act on 'septide-sensitive' tachykinin receptors, thereby stimulating the formation of [3H]-inositol monophosphate ([3H]-IP1) in rat urinary bladder, as evidenced by references [1] [2].

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is an analogue of Substance P that acts on the neurokinin 1 receptor (NK1R) in rat brain, similarly to Substance P but with a significantly extended duration of action. This compound selectively enhances dopamine metabolism within the mesencephalon and midbrain cortex, increases motor activity, and facilitates the resumption of addictive agent-seeking behavior in rats [1] [2] [3].

[Gly11] Substance P, an analog of Substance P itself, functions as a neuropeptide within the CNS, serving dual roles as both a neurotransmitter and neuromodulator [1].

[His11]Substance P, an analog of Substance P (Substance P), functions as both a neurotransmitter and neuromodulator in the central nervous system (CNS) [1].

[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P, a neuropeptide functioning both as a neurotransmitter and neuromodulator in the central nervous system (CNS).

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK 1 receptor antagonist [1] .