β-d-glucuronide-pnp-carbonate

β-D-glucuronide-pNP-carbonate is an ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) can be used in the histochemical analysis of β-glucuronidase activity.

Oroxylin A 7-O-β-d-glucuronide was a new alkaloid which found in the bulbs of Lycoris radiata.

Propofol β-D-glucuronide is a metabolite of propofol sulfate , a short-acting anesthetic agent. [1] [2] The metabolite is generated through the glucuronidation of propofol by uridine diphosphate glucuronosyltransferases. Propofol metabolism appears to occur more rapidly in women than men. [1]

Isoscutellarein 8-O-β-D-glucuronide, a flavonoid antioxidant, can be isolated from the seeds of Theobroma grandiflorum [1] [2].

Resveratrol-4'-O-D-Glucuronide has anti-fat accumulation properties, is metabolized by resveratrol, and can be used in metabolism-related studies.

Ethylmalonic acid is potentially toxic, non-carcinogenic, and has been associated with anorexia nervosa and methoxy decarboxylase deficiency.

Raloxifene 6,4'-Bis-β-D-glucuronide is a Raloxifene metabolite. Raloxifene is a selective antagonist of estrogen receptor for the prevention of osteoporosis.

Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential utility in Alzheimer's disease research [1].

Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan . It does not bind human serum albumin and is cleared from rat plasma with a clearance rate of 180 ml/min/kg following intravenous administration.

Oroxylin A 7-O-β-D-glucuronide methyl ester, a natural product, can be isolated from the roots of Scutellaria baicalensis Georgi [1].

Fulvestrant 3-β-D-Glucuronide, a glucuronide and sulfate conjugate metabolite of the pure anti-estrogenic steroid Fulvestrant, is utilized in breast cancer research [1].

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.

Formoterol O-β-D-glucuronide is a metabolite of formoterol .

all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. It is rapidly converted to all-trans retinoic acid following in vitro or in vivo administration.

Naringenin-7-O-β-D-glucuronide, a metabolite of the flavonoid naringenin, is predominantly synthesized through the action of UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A3, UGT1A6, and UGT1A9.

Tolmetin β-D-Glucuronide has reactive properties with human serum albumin, allowing identification of the binding site and reaction mechanism by tandem mass spectrometry.

Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs), which are innovative therapeutic agents that combine the targeting ability of antibodies with potent cytotoxic drugs.

(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol , which is a metabolite of propranolol. The apparent half-life of (±)-4-hydroxy propranolol β-D-glucuronide is similar to propranolol and 4-hydroxy propranolol. Propranolol is a β-adrenergic antagonist, and the active enantiomer, (S)-(-)-propranolol , has log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.

Perindopril acyl-β-D-glucuronide is a metabolite of the ACE inhibitor perindopril [1].

Naringenin-7-O-beta-D-glucuronide is a natural product

4-Methylumbelliferyl β-D-glucuronide is a useful organic compound for research related to life sciences. The catalog number is T65323 and the CAS number is 6160-80-1.

Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1 1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544(2019) 2.Reese, M.J., Savina, P.M., Generaux, G.T., et al.In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitorDrug Metab. Dispos.41(2)353-361(2013)

Eriodictyol 7-O-β-D-glucuronide ethyl ester is a natural product for research related to life sciences. The catalog number is TN5523 and the CAS number is 847025-48-3.

Luteolin-3-O-beta-D-glucuronide is active in the inhibition of nitrite production in macrophages.

Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide)e has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells.

Ezetimibe-d4 Phenoxy ß-D-Glucuronide is a deuterated compound of Ezetimibe Phenoxy ß-D-Glucuronide. Ezetimibe Phenoxy ß-D-Glucuronide has a CAS number of 190448-57-8.

Curcumin-β-D-glucuronide, a principal metabolite detected in hepatic tissue and portal blood following oral consumption of Curcumin, is utilized in colon cancer research [1] [2].

Naringenin 7-O-β-D-glucuronide methyl ester is a natural product for research related to life sciences. The catalog number is TN5524 and the CAS number is 1985597-72-5.

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

Estriol 16α-(β-D-glucuronide), an endogenous metabolite found in urine, is utilized in pregnancy research [1] [2].

Wogonin 7-O-beta-D-glucuronide methyl ester is a natural product isolated from Huanglian Jiedutang.

Estriol 3-β-D-glucuronide is a metabolite of estriol . It is formed from estriol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A10. Estriol 3-β-D-glucuronide binds to basolateral and canalicular liver plasma membranes with Kd values of 85 and 164 μM, respectively. It competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide and is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc).

Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2]

DiosMetin 7-O-β-D-Glucuronide is an antioxidant component found in lucerne.

5-Hydroxy tryptophol β-D glucuronide-d4 is a deuterated compound of 5-Hydroxy tryptophol β-D glucuronide.

Propofol-d17 β-D glucuronide is a deuterated compound of Propofol7 β-D glucuronide.

Ethyl-β-D-glucuronide-d5 is a deuterated compound of Ethyl-β-D-glucuronide. Ethyl-β-D-glucuronide has a CAS number of 17685-04-0. Ethyl glucuronide is an endogenous metabolite.

Dabigatran acyl-β-D-glucuronide, an active metabolite of the thrombin inhibitor dabigatran, is synthesized predominantly through the action of the UDP-glucuronosyltransferase isoform UGT2B15. This compound, at a concentration of 0.46 µM, effectively prolongs activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.

Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.

6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide is a natural product from Carthamus tinctorius Linn.

Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.

Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) .2,3E217G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.2 1.Loe, D.W., Almquist, K.C., Cole, S.P., et al.ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroidsThe Journal of Biological Chemisty271(16)9683-9689(1996) 2.Gerk, P.M., Li, W., and Vore, M.Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronideDrug Metabolism and Disposition32(10)1139-1145(2004) 3.Gerk, P.M., Li, W., Megaraj, W., et al.Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholateJournal of Pharmacology and Experimental Therapeutics320(2)893-899(2007)

2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic daunomycin .1 1.Leenders, R.G.G., and Scheeren, H.W.Synthesis and evaluation of novel daunomycin-phosphate-sulfate-β-glucuronide and -β-glucoside prodrugs for application in ADEPTBioorg. Med. Chem. Lett.5(24)2975-2980(1995)

Ethynyl estradiol 3-β-D-glucuronide is a metabolite of ethynyl estradiol that can be detected in urine.1,2It is used as a marker of estrogen contamination in fresh and saltwater.2 1.Hadd, H.E., Slikker, W., Jr., and Helton, E.D.The synthesis and characterization of the glucopyranosiduronic acids of 17a-ethynylestradiol-17bJ. Steroid Biochem.13(9)1107-1114(1980) 2.Griffith, D.R., Soule, M.C.K., Eglinton, T.I., et al.Steroidal estrogen sources in a sewage-impacted coastal oceanEnviron. Sci.: Processes Impacts18(8)931-1106(2016)

Mycophenolic acid glucuronide is the glucuronide metabolite of mycophenolic acid in human plasma.