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Results for "

γsecretase modulator 4

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    27
    TargetMol | Activity
IL-17 modulator 4
T365262446803-65-0
IL-17 modulator 4 is a prodrug of IL-17 modulator 1, which is an efficacious modulator of IL-17.
  • $289
In Stock
Size
QTY
γ-Secretase modulator 13
T622631353570-40-7
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.
  • $293
In Stock
Size
QTY
gamma-secretase modulator 1
T113581172637-87-4In house
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
γ-Secretase modulator 4
T113611420200-82-3
γ-Secretase modulator 4 is a potent γ-secretase modulator that reduces Aβ42 levels with IC50s of 0.017 μM in mice and 0.014 μM in humans.
  • $1,670
6-8 weeks
Size
QTY
DPP-4/GPR119 modulator 2
T639642010927-65-6
DPP-4/GPR119 modulator 2 is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 0.22 μM) and an agonist of GPR119 (EC50: 0.95 μM).
  • $1,520
8-10 weeks
Size
QTY
(R)-IL-17 modulator 4
T630892446804-29-9
(R)-IL-17 modulator 4, the R-configured form of IL-17 modulator 4, is a prodrug of IL-17 modulator 1, which is a potent, orally active IL-17 modulator.
  • $996
8-10 weeks
Size
QTY
AMPA receptor modulator-4
T789712917551-59-6
AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). This compound is capable of crossing the blood-brain barrier and has been found to enhance cognitive performance and working memory in mice [1].
  • $1,520
6-8 weeks
Size
QTY
β-Catenin modulator-4
T79103901751-85-7
β-Catenin modulator-4 (compound IIa-92), containing oxazole and thiazole moieties, functions as a potent and selective β-Catenin modulator [1].
  • Inquiry Price
8-10 weeks
Size
QTY
γ-Secretase modulator 10
T403152694817-84-8
γ-Secretase modulator 10 (GSM-10) is a novel compound that modulates γ-secretase activity.
  • $970
Backorder
Size
QTY
Sirtuin modulator 4
T72483327104-77-8
Sirtuin Modulator 4, a sirtuin modulator, exhibits an inhibitory effect on SIRT1, presenting an EC 50 value ranging from 51-100 μM. It is potentially useful in research aimed at prolonging cell lifespan and preventing a broad spectrum of diseases and disorders such as diabetes, obesity, neurodegenerative, cardiovascular diseases, inflammation, and cancer.
  • $1,520
6-8 weeks
Size
QTY
γ-Secretase modulator 14
T876991420200-85-6
  • Inquiry Price
10-14 weeks
Size
QTY
NMDA receptor modulator 4
T609602758256-71-0
NMDA receptor modulator 4 (Compound 169) is a potent NMDA receptor modulator used for neurological disorder research [1].
  • $2,140
8-10 weeks
Size
QTY
RORγt modulator 4
T631242188177-73-1
RORγt modulator 4 is a RORγt modulator that regulates IL-17A production in mouse spleen-derived cells.
  • $1,520
8-10 weeks
Size
QTY
gamma-secretase modulator 1 hydrochloride
T11358L2741571-83-3
Gamma-secretase inhibitor-1 is a gamma-secretase modulator valuable for Alzheimer's disease [1].
  • $1,220
1-2 weeks
Size
QTY
IL-17 modulator 4 sulfate
T401072446806-90-0
IL-17 modulator 4 sulfate is a prodrug of IL-17 modulator 1, which is an orally active and highly efficacious IL-17 modulator.
  • $970
1-2 weeks
Size
QTY
gamma-secretase modulator 2
T113591093978-89-2
Gamma-secretase modulator 2 is a potent, selective compound for the treatment of Alzheimer's disease, specifically designed to modulate γ-secretase activity. This modulation selectively attenuates the production of Aβ(1-42), addressing diseases associated with Aβ deposition in the brain, particularly Alzheimer's disease.
  • $318
6-8 weeks
Size
QTY
CB1R Allosteric modulator 4
T613712633686-53-8
CB1R Allosteric modulator 4 is an effective and positive modulator of cannabinoid type-1 (CB1R), exhibiting significant biological activity. This compound inhibits the production of cAMP and demonstrates strong β-arrestin-2 recruitment [1].
  • $1,520
6-8 weeks
Size
QTY
gamma-secretase modulator 5
T64258
Gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSM) that crosses the blood-brain barrier and inhibits the production of the aggregated amyloid β peptide Aβ42 (IC50: 60 nM). This compound is valuable for studying Alzheimer's disease.
  • $1,520
10-14 weeks
Size
QTY
gamma-secretase modulator 3
T113601431697-84-5
Gamma-secretase modulator 3 [gamma-secretase modulator] is a compound that regulates gamma-secretase activity.
  • $89
5 days
Size
QTY
STING modulator-4
T726152839639-72-2
STING Modulator-4 is a competitive modulator of STING, exhibiting a K_i value of 0.0933 μM for the R232H STING variant. It demonstrates an EC_50 of over 10 μM for p-IRF3 activation in THP-1 cells.
  • $1,670
6-8 weeks
Size
QTY
PCSK9 modulator-4
T607642476490-20-5
PCSK9 modulator-4 (Compound 21) is a potent PCSK9 modulator (EC50 = 0.15 nM) utilized in hyperlipidemia research, targeting the recently validated low-density lipoprotein cholesterol (LDL-C) lowering mechanism [1].
  • $1,520
6-8 weeks
Size
QTY
γ-Secretase modulator 11 hydrochloride
T636382434630-30-3
γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM). γ-Secretase modulator 11 hydrochloride significantly reduces brain Aβ42 levels and rescues the cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has shown research potential in Alzheimer's disease.
  • $1,520
10-14 weeks
Size
QTY
γ-Secretase modulator 11
T632162434630-29-0
5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, significantly reduced brain Aβ42 levels, showed no inhibitory effect on cytochrome p450 enzymes, and demonstrated excellent anti-cognitive deficits in AD model mice.
  • $1,520
6-8 weeks
Size
QTY
Kv3 modulator 4
T117902173375-10-3
Kv3 modulator 4 is a cyclobutyl-structured modulator of Kv3.1 (pEC50=5.45) and Kv3.2 channels.
  • $2,120
8-10 weeks
Size
QTY
γ-Secretase modulator 12
T618812204249-82-9
γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM, specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain plasma ratio (Kp, brain = 0.72) in mice [1].
  • $1,520
6-8 weeks
Size
QTY
mGluR2 modulator 4
T612772582758-47-0
4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC50 value of 0.8 μM, with potential for investigating antipsychotic properties [1].
  • $1,520
6-8 weeks
Size
QTY
DPP-4/GPR119 modulator 1
T745282411099-68-6
DPP-4 GPR119 modulator 1 (Compound 22) is an orally active compound that acts as both a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist, demonstrating a glucose-lowering effect in blood and moderate inhibition of the hERG channel with an IC50 value of 4.9 µM. This compound is applicable in diabetes research [1].
  • Inquiry Price
Size
QTY