15,16epoxy12shydroxylabda8(17),13(16),14triene

Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.

Compound 9, 15-Nor-14-oxolabda-8(17),12E-diene-18-oic acid, is an isolated compound derived from the roots of Chloranthus spicatus [1].

8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione is a natural product for research related to life sciences. The catalog number is TN5610 and the CAS number is 76497-89-7.

3,21-Dihydroxy-14-serraten-16-one is a natural product for research related to life sciences. The catalog number is TN2859 and the CAS number is 24513-51-7.

ent-14,16-Epoxy-8-pimarene-3,15-diol is a natural product for research related to life sciences. The catalog number is TN3935 and the CAS number is 1188281-98-2.

9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory effect of the pine needles and may play an important role in the allelopathy of red pine.

ent-17-Hydroxykaur-15-en-19-oic acid is a natural compound found in the leaves of the aromatic tree and has an IC50 of 17.63microg/mL on human prostate cells.

The compound is extracted from Croton tiglium dried fruit.

17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene is a sesquiterpene lactone of natural origin that exhibits anti-inflammatory properties [1].

ent-Labda-8(17),13E-diene-3beta,15,18-triol is a natural product for research related to life sciences. The catalog number is TN3960 and the CAS number is 90851-50-6.

ent-6,11-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3951 and the CAS number is 81263-97-0.

4(15),5,10(14)-Germacratrien-1-ol is a natural product for research related to life sciences. The catalog number is TN2997 and the CAS number is 81968-62-9.

ent-11alpha-Hydroxyabieta-8(14),13(15)-dien-16,12alpha-olide shows significant cytotoxic activity against ANA-1 and Jurkat cells with IC50 values 7.12 x 10(-3) and 1.79 x 10(-2) microM.

Compound 4, 14-Benzoylmesaconine-8-palmitate, is a lipo-alkaloid that can be isolated from A. toxicum [1].

15,16-Epoxy-12R-hydroxylabda-8(17),13(16),14-triene is a natural product for research related to life sciences. The catalog number is TN2631 and the CAS number is 61597-55-5.

8(17),13-Labdadien-15,16-olide is a natural product for research related to life sciences. The catalog number is TN3263 and the CAS number is 83324-51-0.

Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester) is a natural product for research related to life sciences. The catalog number is TN6498 and the CAS number is 1309929-72-3.

15,16-Dinor-8(17),11-labdadien-13-one is a natural product for research related to life sciences. The catalog number is TN2630 and the CAS number is 76497-69-3.

9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME (1 g/animal) enhances the antiviral IgA and IgG antibody responses induced by a nasal influenza hemagglutinin (HA) vaccine by 5.2- and 2-fold, respectively, in mice.4 1.Hamberg, M., and Hamberg, G.Peroxygenase-catalyzed fatty acid epoxidation in cereal seeds: Sequential oxidation of linoleic acid into 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acidPlant Physiol.110(3)807-815(1996) 2.Hong, S.S., and Oh, J.S.Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from wheat branJ. Korean Soc. Appl. Biol. Chem.5569-74(2012) 3.Kim, C.S., Kwon, O.W., Kim, S.Y., et al.Five new oxylipins from Chaenomeles sinensisLipids49(11)1151-1159(2014) 4.Shirahata, T., Sunazuka, T., Yoshida, K., et al.Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acidsTetrahedron62(40)9483-9496(2006) 5.Fuchs, D., Tang, X., Johnsson, A.-K., et al.Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent processBiochim. Biophys. Acta Mol. Cell Biol. Lipids1865(4)158611(2020)

Selina-4(15),7(11)-dien-8-one is a natural product for research related to life sciences. The catalog number is TN3467 and the CAS number is 54707-47-0.

(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a natural product for research related to life sciences. The catalog number is TN6216 and the CAS number is 56682-25-8.

(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid, a phytotoxin recently identified in Alternaria alternata ssp. tenuissima isolates, is associated with fruit spots on apples.

14-Deoxy-17-hydroxyandrographolide is a natural product of Andrographis, Acanthaceae. The catalog number is TN2623 and the CAS number is 869384-82-7. 14-Deoxy-17-hydroxyandrographolide can be used as a reference standard.

15,16-Epoxy-12S-hydroxylabda-8(17),13(16),14-triene is a natural product for research related to life sciences. The catalog number is TN2632 and the CAS number is 216011-55-1.

14-Benzoyl-8-O-methylaconine is a natural product for research related to life sciences. The catalog number is TN6117 and the CAS number is 93772-68-0.

19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide is a natural product for research related to life sciences. The catalog number is TN2661 and the CAS number is 919120-78-8.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3955 and the CAS number is 81263-96-9.

16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity.

ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3953 and the CAS number is 81264-00-8.

8(17),12E,14-Labdatrien-20-oic acid is a natural product from Isodon yuennanensis.

ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside is a natural product for research related to life sciences. The catalog number is TN3961 and the CAS number is 1245636-01-4.

16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expre

1,2-Epoxy-10(14)-furanogermacren-6-one is a natural product for research related to life sciences. The catalog number is TN6491 and the CAS number is 383368-24-9.

15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one is a natural product for research related to life sciences. The catalog number is TN2633 and the CAS number is 1374328-47-8.

ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation of the endothelial NO-cGMP pathway, the opening of K+ channels and the alteration on Ca2+ mobilization.

16-Nor-15-oxodehydroabietic acid is a natural product from Pinus massoniana.

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.

8(14),15-Isopimaradiene-3,18-diol is a natural product for research related to life sciences. The catalog number is TN3261 and the CAS number is 59219-64-6.

9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.

ent-17-Hydroxykaura-9(11),15-dien-19-oic acid is a natural product from Wedelia trilobata.

(4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al is a natural product for research related to life sciences. The catalog number is TN2998 and the CAS number is 935293-70-2.

ent-7alpha,9-Dihydroxy-15-oxokaur-16-en-19,6bet-olide is a natural product for research related to life sciences. The catalog number is TN3954 and the CAS number is 59885-89-1.

7,15-Dihydroxypodocarp-8(14)-en-13-one is a natural product for research related to life sciences. The catalog number is TN3206 and the CAS number is 262355-96-4.

16-Hydroxy-8(17),13-labdadien-15,16-olid-19-oic acid may show a strong algicidal activity against Raphidocelis subcapitata.

ent-3beta,18-Dihydroxylabda-8(17),13E-dien-15-oic acid is a natural product for research related to life sciences. The catalog number is TN3947 and the CAS number is 99624-39-2.

3α-Cinnamoyloxy-9β,17-dihydroxy-ent-kaur-15-en-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5613 and the CAS number is 2186648-60-0.

3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic acid, a microalgal polyunsaturated fatty acid (PUFA), is identified in G. kowalevskii and serves as a chemotaxonomic biomarker for microalgae and dinoflagellates.

14-Deoxy-12-hydroxyandrographolide is a natural product of Andrographis, Acanthaceae. The catalog number is TN5586 and the CAS number is 219721-33-2. 14-Deoxy-12-hydroxyandrographolide can be used as a reference standard.

12-Hydroxy-8(17),13-labdadien-16,15-olide is a natural product for research related to life sciences. The catalog number is TN2598 and the CAS number is 958885-86-4.

15-Methoxy-16-oxo-15,16H-strictic acid is a natural product of Pulicaria, Asteraceae. The catalog number is TN6526 and the CAS number is 1356388-38-9. 15-Methoxy-16-oxo-15,16H-strictic acid can be used as a reference standard.