TN5166 |
Trans-Methylisoeugenol
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GST
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Parasite
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Trans-Methylisoeugenol 是从 Acorus calamus L 中分离得到的具有杀虫活性的化合物。它 是一种天然食用香料,具有抗焦虑和抗抑郁等特性,可对谷胱甘肽 S-转移酶(GSTs)产生中度可逆性抑制作用(对人类 ... |
T11505 |
GSTO1-IN-1
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GST
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Glutathione Peroxidase
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GSTO1-IN-1 是谷胱甘肽 S-转移酶 omega 1 抑制剂,IC50=31 nM。 |
T3S0541 |
Curzerene
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莪术烯,莪术呋喃烯 |
Apoptosis
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GST
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Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cance... |
T3S0012 |
Coniferyl ferulate
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GST
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P-gp
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Coniferyl ferulate 是从川芎中提取的一种天然产物,是强效的谷胱甘肽 S-转移酶抑制剂,强抑制人胎盘型谷胱甘肽 S-转移酶,IC50为 0.3 μM。它还可逆转多药耐药性并下调 P-糖蛋白。 |
T5S1285 |
(+)-(3R,8S)-Falcarindiol
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Falcarindiol,镰叶芹二醇 |
Others
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Falcarindiol 是一种从胡萝卜中得到的聚乙炔,有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用,对Mycobacterium tuberculosisH37Ra 的最低抑制浓度 MIC 和 IC50值分别为 24 μM 和 ... |
T5097 |
Ezatiostat
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TLK199,TER199(free base) |
GST
,
Glutathione Peroxidase
,
Apoptosis
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Ezatiostat 是一种谷胱甘肽的三肽类似物,也是一种选择性的口服活性的谷胱甘肽 S-转移酶 P1-1 (GSTP1) 抑制剂。它通过抑制GSTP1导致 JNK 激活,刺激淋巴细胞生成和骨髓祖细胞增殖,可研究骨髓增生异常综合症。 |
TN1078 |
Seneciphylline
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千里光非灵,千里光菲灵碱 |
GST
,
P450
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Seneciphylline 是一种有毒的吡咯烷核生物碱,存在于千里光植物中。它显著增加了环氧水合酶和谷胱甘肽-S-转移酶的特性,但导致细胞色素 P-450 和相关单加氧酶特性的抑制。 |
T4564 |
Ethacrynic acid
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利尿酸,Etacrynic Acid,Edecrin,Hydromedin |
Others
,
NF-κB
,
Calcium Channel
,
GST
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Ethacrynic acid 是谷胱甘肽 S-转移酶抑制剂,也是NF-κB 信号传导途径的有效抑制剂,并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道,从而导致气道平滑肌细胞松弛。它是利尿剂,具有抗炎特性,可减轻类维... |
T7995 |
α-Angelica lactone
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α-当归内酯,Alpha-Angelica Lactone,当归内酯 |
Others
,
GST
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Alpha-Angelica Lactone 是一种乙烯基亲核试剂,也是一种天然存在的抗癌剂。它可以得到手性的 δ-氨基 γ,γ-二取代丁烯醇内酯羰基衍生物,并在 γ-碳上表现出亲电子俘获。它通过选择性增强谷胱甘肽-S-硫转移酶 (GST)... |
TMPY-00539 |
GSTA1 Protein, Human, Recombinant (His Tag), HPLC-verified
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GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. This gene encodes a member of a family of enzymes th... |
TMPY-02223 |
GSTM2 Protein, Human, Recombinant (His Tag)
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Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to... |
TMPY-03450 |
GSTK1 Protein, Human, Recombinant
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GSTK1 gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in ce... |
T11240 |
Ethacrynic acid D5
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Others
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Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airw... |
TMPY-03338 |
GSTZ1 Protein, Human, Recombinant (His Tag)
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GSTZ1 (Glutathione S-Transferase Zeta 1) is a Protein Coding gene. 3 alternatively spliced human isoforms have been repo... |
T22776 |
Ezatiostat hydrochloride
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TER199,TLK199 HCl,Ezatiostat盐酸盐 |
Glutathione Peroxidase
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Ezatiostat hydrochloride 是一种新型谷胱甘肽类似物,可刺激淋巴细胞生成和骨髓祖细胞增殖,可用于治疗血细胞减少症和研究骨髓增生异常综合症。它也是口服活性的选择性谷胱甘肽 S-转移酶 P1-1 抑制剂,通过抑制 GSTP... |