a-01

A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cultures.

A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and ALK7 induced transcription, respectively [1].

A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.

Leramistat (HMC-C-01-A; MBS2320), a mitochondrial complex 1 inhibitor, plays a role in regulating cell and immune metabolism. It is effective in suppressing various conditions, including atopic dermatitis, autoimmune skin diseases, inflammatory disorders, cancer, and osteoclast-mediated diseases [1].

NMO-IgG blocker A-01 is a idiotype-specific blocker of neuromyelitis opticaimmunoglobulin g (nmo-igg) binding to aquaporin-4 (aqp4)

Xenopsin(2TFA) is a neurotensin-like octapeptide previously isolated from amphibian skin.

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].

C-Reactive Protein (CRP) 77-82 acetate is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.C-reactive protein (CRP) is an annular (ring

Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 acetate(1095179-01-3 free base) selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.

Pyrazinecarboxamide, 3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo- is a useful organic compound for research related to life sciences. The catalog number is TNU0422L and the CAS number is 356783-01-2.This compound is unstable in powder form and other related salt forms are recommended.

LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be used to study breast cancer.

HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).

AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.

HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respectively.

Fluoroscein NAD+ is a substrate for ADP-ribosylation, providing a convenient non-isotopic alternative to radiolabelled NAD for use in PARP assays. Allows direct measurement of NAD-dependent enzymes, such as PARP, by fluorescence microscopy. This product is a replacement for R&D Systems product 4673-500-01 81 μg is supplied as 250 μl of a 0.25 mM solution in water.

BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.

Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide that specifically targets the splicing of exon 53 in the dystrophin gene. It is utilized in research related to Duchenne muscular dystrophy (DMD).

Mirificin-4'-O-glucoside is a natural product for research related to life sciences. The catalog number is TN6436 and the CAS number is 168035-01-6.

Augustifolin is a natural product for research related to life sciences. The catalog number is TN3470 and the CAS number is 66548-01-4.

[D-Ala2]leucine-enkephalin acetate ([D-Ala2]leucine-enkephalin acetate (64963-01-5 free base)) is a delta opioid agonist used to study the signaling pathway of delta opioid receptors.

CCD Lipid01 (LP-01) is a lipid membrane that can be used to deliver biologically active agents .

NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that facilitates the nuclear import of cytosolic cargoes by leveraging the nuclear-localized bromodomain-containing protein 4 (BRD4) as a carrier for their co-import and subsequent nuclear entrapment [1].

HG-7-85-01 is a type II ATP competitive inhibitor targeting wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. It effectively inhibits T315I mutant Bcr-Abl kinase, as well as KDR and RET kinases with IC50 values of 3 nM, 20 nM, and 30 nM, respectively. In contrast, HG-7-85-01 exhibits weak or no inhibition towards other kinases (IC50 >2 μM). Furthermore, this compound inhibits cell proliferation through the induction of apoptosis and by impeding cell-cycle progression.

Glycyrrhiza flavonol A is a natural product of Glycyrrhiza, Fabaceae. The catalog number is TN4150 and the CAS number is 197304-01-1. Glycyrrhiza flavonol A can be used as a reference standard.

7-(3'-Carboxybutoxy)coumarin is a natural product for research related to life sciences. The catalog number is TN6209 and the CAS number is 16851-01-7.

Tricin 7-O-glucoside is a natural product for research related to life sciences. The catalog number is TN5547 and the CAS number is 32769-01-0.

DL-01 is a drug-linker conjugate for antibody-drug conjugates (ADCs), utilized in the synthesis of ADCs [1].

16-O-Acetyldarutigenol is a natural product of Siegesbeckia, Asteraceae. The catalog number is TN5571 and the CAS number is 1188282-01-0. 16-O-Acetyldarutigenol can be used as a reference standard.

3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane is a natural product for research related to life sciences. The catalog number is TN2897 and the CAS number is 408324-01-6.

Neochlorogenin 6-O-α-L-rhamnopyranosyl-(1→3)-β-D-quinovopyranoside is a natural product for research related to life sciences. The catalog number is TN6326 and the CAS number is 184686-01-9.

(-)-Calcium hydroxycitrate tribasic, with the CAS number 921226-01-9, is a chemical compound.

Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity agent.

Quercetin 3-O-(6-O-malonyl)-b-D-glucoside is a useful organic compound for research related to life sciences. The catalog number is T123838 and the CAS number is 96862-01-0.

YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.

(2S,3S)-2-((2S,3S)-2-(((Benzyloxy)carbonyl)amino)-3-methylpentanamido)-3-methylpentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65505 and the CAS number is 42538-01-2.

3HOI-BA-01 is a mammalian targeting effective rapamycin activation inhibitor.

(S)-Diphenyl(pyrrolidin-2-yl)methanol is a useful organic compound for research related to life sciences. The catalog number is T65609 and the CAS number is 112068-01-6.

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T67188 and the CAS number is 881386-01-2.

1-Benzylpiperidin-3-ol is a useful organic compound for research related to life sciences. The catalog number is T64873 and the CAS number is 14813-01-5.

DM-01 is a potent and selective inhibitor of EZH2. DM-01 can be used to study diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and SNF5/INI-1/SMARCB1 gene-associated solid tumours.

(E/Z)-10-Hydroxy-2-decenoic acid is a useful organic compound for research related to life sciences. The catalog number is T124254 and the CAS number is 765-01-5.

Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).

OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).

Catechin pentaacetate is a natural product of Taxus, Taxaceae. The catalog number is TN3610 and the CAS number is 16198-01-9. Catechin pentaacetate can be used as a reference standard.

Triclosan methyl-d3 (methoxy-d3) is a deuterated compound of Triclosan methyl. Triclosan methyl has a CAS number of 4640-01-1. Triclosan-methyl is a transformation product of triclosan. Triclosan is a bactericide in personal care products such as toothpaste, shampoos, and soaps. Triclosan is also a stabilizing agent in a multitude of detergents and cosmetics.

Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine-(2-(2-aminoethyl)phenyl)palladium(II) chloride is a useful organic compound for research related to life sciences. The catalog number is T66227 and the CAS number is 1148148-01-9.

Asperflavine is a useful organic compound for research related to life sciences. The catalog number is T124922 and the CAS number is 38371-01-6.

Benzyl (4-bromo-3-fluorophenyl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66461 and the CAS number is 510729-01-8.

5-Chlorohexanoyl chloride is a useful organic compound for research related to life sciences. The catalog number is T64515 and the CAS number is 99585-01-0.