abt-418 hydrochloride

ABT-418 hydrochloride is a selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. It activates cholinergic channel and can be used for the research of Alzheimer's disease.

ABT-418, a nicotinic acetylcholine receptor (nAchR) agonist, is used potentially for the treatment of attention deficit disorder.

ABT-702 hydrochloride effectively inhibits adenosine kinase, exhibiting an IC50 value of 1.7 nM [1] [2].

Potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

ABT-491 hydrochloride is an active platelet activator receptor (PAF-R) antagonist with good selectivity and oral administration.

ABT-639 hydrochloride is a selective, novel T-type Ca2+ channel blocker.

Epiboxidine hydrochloride, a methylisoxazole analog of the alkaloid Epibatidine and an analog of the nAChR agonist ABT 418 [1], serves as a potent and selective agonist of neural nAChRs, demonstrating K i values of 0.46 nM and 1.2 nM for α4β2 nAChRs in rats and humans, respectively.