ac 4 130

AC-4-130, a powerful inhibitor of the SH2 domain of STAT5, effectively hinders STAT5 activation, dimerization, nuclear translocation, and transcription of genes reliant on STAT5. This compound directly binds to STAT5, ultimately leading to cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 exhibits notable anti-cancer properties and effectively suppresses abnormal STAT5 activity in acute myeloid leukemia (AML), making it a promising therapeutic option [1].

AC-4 is a blocker of photoswitchable TRPV1 channel.

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect in rat models [1] [2].

8-Daucene-2,4,6-triol, O-(4-Hydroxybenzoyl), 2-Ac is a useful organic compound for research related to life sciences and the catalog number is T130945.

Ac-MBP (4-14) Peptide, an acetylated form of the MBP (4-14) peptide, serves as a highly selective substrate for (protein kinase C) PKC. It facilitates PKC assays in extracts without the need for prior purification to remove interfering protein kinases or phosphatases [1].

ZXH-4-130 is a potent and selective CRBN degrader, functioning as a hetero-PROTAC compound with the inclusion of CRBN-VHL.

ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of CRBN. At a concentration of 10 nM in MM1.S cells, ZXH-4-130 TFA achieves approximately 80% degradation of CRBN [1].

H-Phe(4-Ac)-OH is a useful organic compound for research related to life sciences. The catalog number is T66400 and the CAS number is 122555-04-8.