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Results for "

ac-0010

" in TargetMol Product Catalog
  • Inhibitor Products
    3
    TargetMol | Activity
Avitinib maleate
T37211557268-88-8
Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
  • $67
In Stock
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Avitinib
T30241557267-42-1
Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of Ys, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.
  • $41
In Stock
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Lurtotecan dihydrochloride
T70445155773-58-3
Lurtotecan dihydrochloride is an antineoplastic (DNA Topoisomerase I Inhibitor)
  • $2,570
1-2 weeks
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