acid peg4 s s peg4 acid

Acid-PEG4-S-S-PEG4-acid, a polyethylene glycol (PEG)-based PROTAC linker, is a crucial component in PROTAC synthesis.

Acid-PEG4-S-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules and enables selective protein degradation through the ubiquitin-proteasome system within cells.

(S)-TCO-PEG4-acid is a PEG-based linker for PROTACs, joining two essential ligands critical for PROTAC molecule formation, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Propargyl-PEG4-S-PEG4-acid, a polyethylene glycol (PEG)-based PROTAC linker, is suitable for synthesizing Proteolysis Targeting Chimera (PROTACs) [1].

Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].

(S,R,S)-AHPC (VH032-NH2) is a VH032-based ligand for recruiting the von Hippel-Lindau (VHL) protein, potentially useful for the targeted degradation of the androgen receptor.

N3-PEG4-C2-NHS ester is a noncleavable, four-unit polyethylene glycol (PEG) linker essential for the synthesis of antibody-drug conjugates (ADCs).

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs

Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based linker utilized in the synthesis of PROTACs.

(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).

11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker used in PROTAC synthesis (PROTAC is an acronym for [PROteolysis-TArgeting Chimera]).

6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).

Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].

11-Aminoundecanoic acid, an alkyl chain-based PROTAC linker, is employed in PROTAC synthesis.

Boc-11-aminoundecanoic acid is an alkyl ether-based PROTAC linker used in the synthesis of [MS432].

DSPE-PEG-OH (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.

Cbz-NH-PEG12-C2-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands to form PROTAC molecules, thereby enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-PEG7-acid, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and 4-unit PEG linker.

Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.

Aminooxy-PEG4-alcohol is both a non-cleavable 4-unit PEG ADC linker and a PEG-based PROTAC linker.

(S,R,S)-AHPC-Me-C10-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating a VHL ligand and a linker.

Azido-PEG4-azide is a PEG-based PROTAC linker used for synthesizing PROTACs.

Thalidomide-PEG4-Propargyl (Thalidomide-O-PEG4-Propargyl) is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker which can be used in PROTAC technology[1].

m-PEG7-4-nitrophenyl carbonate is a PEG-based PROTAC linker used in PROTAC synthesis [1].

CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protein. CPI-0610 carboxylic acid may have anticancer and anticancer activities.

(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate, comprising an (S,R,S)-AHPC-based VHL ligand and a linker, designed for BET-targeted PROTAC applications.

Pomalidomide-C2-acid is a PROTAC building block.

Acid-C1-PEG5-Boc, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to create PROTACs (e.g., GMB-475), which effectively induce the degradation of BCR-ABL1, demonstrated by an IC50 of 1.11 μM in Ba/F3 cells.

(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic, and pro-apoptotic activities, used in studying leprosy erythema nodosum and myeloma.

Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an efficient pegylated PROTAC linker commonly used in the synthesis of chloroanes (HaloPROTACs).

BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).

JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is utilized in the synthesis of ARV-771, a potent BET protein degrader. It selectively degrades BET protein in castration-resistant cells with a DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, it serves as the VHL ligand from (S,R,S)-AHPC for recruiting von Hippel-Lindau (VHL) protein.

MS-PEG4-THP is a PROTAC linker, which is a PEG type.

Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker utilized in PROTAC synthesis.

DBCO acid 2 is a Click Chemistry intermidate used for antibody-drug conjugates.

(S,R,S)-AHPC is a VHL ligand that used in the recruitment of the VHL protein.

Biotin-PEG8-acid is a PEG-based PROTAC linker labeled with biotin, utilized in PROTAC synthesis.

Amino-PEG12-acid, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

m-PEG12-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs.

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate that includes the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker used in the synthesis of PROTAC.

(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].