active-mono-sulfone-peg-8-acid

Active-mono-sulfone-PEG8-acid, a polyethylene glycol (PEG) derivative, serves as a linker for PROTAC synthesis [1].

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Sulfone-Bis-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG3-Sulfone-PEG4-acid, a polyethylene glycol (PEG) derivative, is frequently employed as a linker in the construction of proteolysis targeting chimeras (PROTACs) [1].

Acid-PEG4-mono-methyl ester, a PEG- and Alkyl ether-based PROTAC linker, can be employed for PROTAC synthesis[1].

Acid-PEG6-mono-methyl ester is a polyethylene glycol (PEG)-based PROTAC linker suitable for the synthesis of PROTACs [1].

Acid-PEG5-mono-methyl ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Acid-PEG3-mono-methyl ester, an alkyl ether-based PROTAC linker, facilitates the synthesis of PROTACs[1].

m-PEG3-Sulfone-PEG3-acid is a polyethylene glycol (PEG)-based linker used in protein degradation via targeted chimera (PROTAC) [1].

Propargyl-PEG4-Sulfone-PEG4-acid serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].