adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH), a polypeptide tropic hormone secreted by the anterior pituitary gland, regulates cortisol and androgen production [1] [2].

Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) is an agonist of potent melanocortin(MC4R) receptor .

Adrenocorticotropic Hormone (ACTH) (1-39), rat, is a potent melanocortin 2 (MC2) receptor agonist. Peptide fragments of ACTH (1-39) were formed during in vitro incubation with membrane preparations, isolated by high-pressure liquid chromatography, and characterized by determining their amino acid composition and NH2-terminal residue.

Adrenocorticotropic Hormone (ACTH) (4-10) is a potent agonist of the melanocortin receptor (MC4R).

Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA), is a potent agonist of the melanocortin 2 receptor (MC2).

Adrenocorticotropic Hormone (ACTH) (1-10), human, is a fragment of adrenocorticotropin hormone. It demonstrates weak α-melanocyte stimulating hormone (α-MSH) potency, which is only apparent at high doses (100 and 1000 nM).

Adrenocorticotropic Hormone (ACTH) (18-39), also known as the Corticotropin-like Intermediate Lobe Peptide, stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to secretin and carbamylcholine.

Adrenocorticotropic hormone (ACTH) TFA, a polypeptide tropic hormone synthesized by the anterior pituitary gland, regulates the production of cortisol and androgens [1] [2].

ACTH 11-24 acetate(4237-93-8 free base) (Adrenocorticotropic Hormone (11-24) acetate) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.

ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland. ACTH is an important component of the hypothalamic-pituitary-adrenal axis as a response to biological stress.

Adrenocorticotropic Hormone (ACTH) (1-10), human acetate is a fragment of adrenocorticotropin hormone. Adrenocorticotropic Hormone (ACTH) (1-10), human acetate possesses a weak α-MSH potency only at 100 and 1000 nM.

Adrenocorticotropic Hormone (ACTH) (1-39), human, is an agonist of the melanocortin receptor.

ACTH (1-14), a fragment of adrenocorticotropin, governs the production of cortisol and androgens.

ACTH (22-39) is a fragment of the adrenocorticotropic hormone (ACTH), specifically comprising the 22-39 sequence of ACTH.

Adrenocorticotropic hormone (6-24) (ACTH (6-24) (human)) is a fragment of ACTH that acts as a competitive inhibitor of steroidogenesis prompted by full-length ACTH (1-39) and the shortened ACTH (5-24), with dissociation constants (Kd) of 13.4 nM and 3.4 nM, respectively. It also impedes the production of corticosterone and the accumulation of cyclic AMP (cAMP) triggered by human parathyroid hormone (hPTH 1-34) [1] [2].

ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response.

Adrenocorticotropic Hormone (ACTH) (1-39) human (TFA), a member of the melanocortin family, is a melanocortin receptor agonist that stimulates corticosteroid production by the adrenals; melanocortin receptors are also located in the central nervous system (CNS) and on immune cells.

ACTH (1-14) (TFA) is a polypeptide of corticotrophin, which promotes the release of cortisol.

ACTH (11-24) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.

ACTH (1-13) is a 13-aa peptide with cytoprotective effects in a model of ethanol-induced gastric lesions in rats. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland and plays a critical role in the hypothalamic-pituitary-adrenal axis in response to biological stress.

ACTH (22-39) acetate is a fragment of adrenocorticotropic hormone (ACTH) containing two proline residues at positions 3 and 15 from the N-terminus.

Tildacerfont is an antagonist of CRF1 and reduces the levels of adrenocorticotropic hormone and adrenal androgen. Tildacerfont can be used in studies about congenital adrenal hyperplasia.

Tetracosactide (Tetracosactrin) (INN) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone.

Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.

Adrenocorticotropic Hormone (ACTH) (18-39), human TFA (CLIP human TFA) is a corticotropin-like intermediate lobe peptide produced in the melanotrophs of the pituitary's intermediate lobe.

20α-Dihydro Prednisolone, a prednisolone metabolite, is detected in cattle urine post-adrenocorticotropic hormone (ACTH) administration but absent in both naturally stressed and non-stressed cattle.

α-Helical CRF (9-41) is a synthetic peptide antagonist that targets corticotropin-releasing factor (CRF), effectively inhibiting CRF-induced adrenocorticotropic hormone (ACTH) release both in vitro, with isolated rat anterior pituitary cells at concentrations of 0.5 to 5 µM, and in vivo, in non-anesthetized, intact rats at doses ranging from 0.02 to 0.6 µmol/kg. Moreover, it prevents stress-induced ACTH release at a dose of 0.6 µmol/kg in rats and demonstrates the ability to enhance social interaction times in a rat model addressing nicotine-induced conditioned anxiety, in addition to decreasing binge-like ethanol consumption in mice.

[Tyr^0] Corticotropin Releasing Factor, ovine, is a hypothalamic hormone sourced from sheep that prompts the secretion of adrenocorticotropic hormone (ACTH) and β-endorphin [1] [2].

NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].

Alsactide, an adrenocorticotropic hormone (ACTH) agonist and a heptadecapeptide analogue, is utilized in the study of the central nervous system [1].

[Asu1,6-Arg8]Vasopressin is a vasopressin agonist that enhances cyclic AMP accumulation and adrenocorticotropic hormone (ACTH) release triggered by corticotropin-releasing factor (CRF) in cultured rat anterior pituitary cells [1] [2].

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

ACTH (7-38) (human) is a fragment (7-38) of the full human adrenocorticotropic hormone (ACTH (1-39)), also known as corticotropin inhibitory peptide (CIP). It functions as an antagonist to the ACTH receptor and lacks corticosteroid activity [1].

CRN04894 (compound 17h), an orally active MC2R antagonist, effectively inhibits adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion in a rat model[1]. It exhibits strong binding to MC2R in both human and rat, with K B values of 0.34 nM and 0.23 nM, respectively[1].

(Des-His^6)-ACTH (1-24) (human, bovine, rat) is an adrenocorticotropic hormone (ACTH) analog. Produced by the anterior pituitary gland, ACTH is a polypeptide tropic hormone that regulates the production of cortisol and androgens [1].

Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.

ACTH (34-39), an adrenocorticotropic hormone fragment, is a peptide sequence comprising amino acids 34 to 39.

ACTH (11-24) (acetate), a fragment of adrenocorticotropic hormone (ACTH), functions as a receptor antagonist and promotes cortisol release. This compound is utilized in researching the central nervous system [1].

[DPro5] Corticotropin Releasing Factor, human, rat, a selective R2 agonist of corticotropin-releasing factor hormone (CRF), is a hypothalamic hormone that prompts the release of adrenocorticotropic hormone (ACTH) and β-endorphin. Unlike typical agents, it does not induce anxiogenic effects but instead influences learning and memory processes in rats [1].

R121919 (NBI30775) is a potent small molecule antagonist of the adrenocorticotropic hormone-releasing factor receptor 1 (CRF1), demonstrating antidepressant and anxiolytic activity, and inhibiting the CRF1 receptor, CRF2 receptor, and CRF-binding proteins.

Efonidipine HCl (NZ-105) serves as both a T-type and L-type calcium channel blocker. This compound, distinct from other calcium channel blockers, notably increases N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA and DHEA-S production in NCI-H295R adrenocortical carcinoma cells, actions reflective of adrenocorticotropic hormone. Efonidipine uniquely inhibits calcium channels by merging tonic and use-dependent blocking methods. Its inhibitory concentrations (IC50) for I(Ca(T)) and I(Ca(L)) are 0.35 micromol/l and 1.8 nmol/l, respectively. Clinically, efonidipine administered to hypertensive patients undergoing chronic hemodialysis (20-60 mg, twice daily) demonstrated comparable blood pressure control to amlodipine (2.5-7.5 mg, once daily) over a 12-week period without significantly altering pulse rate. Furthermore, efonidipine significantly improved left ventricular ejection fraction in heart failure models without affecting blood pressure, in addition to lowering the heart rate by about 10%.

Stressin I (Cyclo(31-34)[DPhe12, Nle21, 38, Glu31, Lys34]Ac-hCRF(4-41)) TFA, with a K i of 1.7 nM, is a potent and selective agonist of the CRF1 receptor that elevates adrenocorticotropic hormone (ACTH) levels in rats [1].

ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland.

ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat), the fragment spanning amino acids 3-24 of adrenocorticotropic hormone (ACTH), serves as a research tool in studying illnesses such as cancer, immune diseases, and cardiovascular disease [1].

(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an adrenocorticotropic hormone (ACTH) analogue synthesized by the anterior pituitary gland to regulate cortisol and androgen production. This polypeptide tropic hormone variant differs from ACTH by the absence of glutamic acid at the fifth position.