adrenocorticotropic hormone (acth) (4 10), human

Adrenocorticotropic Hormone (ACTH) (4-10) is a potent agonist of the melanocortin receptor (MC4R).

Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].

Human growth hormone-releasing factor acetate is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary[1].

Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.

Adrenocorticotropic Hormone (ACTH) (1-10), human acetate is a fragment of adrenocorticotropin hormone. Adrenocorticotropic Hormone (ACTH) (1-10), human acetate possesses a weak α-MSH potency only at 100 and 1000 nM.

Acth (1-4) acetate is the ACTH N-terminal tetrapeptide.

ACTH 4-11 acetate is an adrenocorticotropin hormone fragment and possesses the same amino acid sequence as α-melanocyte stimulating hormone (MSH) does. ACTH 4-11 acetate exhibits a weak MSH potency only at high doses (100 and 1000 nM).

Adrenocorticotropic Hormone (ACTH) (18-39), human TFA (CLIP human TFA) is a corticotropin-like intermediate lobe peptide produced in the melanotrophs of the pituitary's intermediate lobe.

Saralasin acetate is a Non-selective angiotensin II antagonist.

Adrenocorticotropic Hormone (ACTH) (1-39), human, is an agonist of the melanocortin receptor.

Acth (1-4) is the ACTH N-terminal tetrapeptide.

(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective agonist for the NK-2 tachykinin receptor [1].

Acetyl-ACTH (4-24) (human, bovine, rat), a proopiomelanocortin (POMC) peptide fragment, functions as an agonist at the MC-1 receptor [1]. This compound encompasses a sequence present in adrenocorticotrophin (ACTH), the precursor for α-MSH, illustrating its significant role in the POMC peptide family.

Acetyl-ACTH (7-24) (human, bovine, rat) effectively inhibits corticosterone and aldosterone secretion triggered by ACTH stimulation [1].

(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an adrenocorticotropic hormone (ACTH) analogue synthesized by the anterior pituitary gland to regulate cortisol and androgen production. This polypeptide tropic hormone variant differs from ACTH by the absence of glutamic acid at the fifth position.

Adrenocorticotropic Hormone (ACTH) (18-39), also known as the Corticotropin-like Intermediate Lobe Peptide, stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to secretin and carbamylcholine.

Adrenocorticotropic hormone (ACTH) TFA, a polypeptide tropic hormone synthesized by the anterior pituitary gland, regulates the production of cortisol and androgens [1] [2].

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a potent and highly selective NK2 receptor agonist with an IC50 value of 6.1 nM [1].

β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose. It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 μM.

Platelet Factor 4 (58-70), human, is a polypeptide comprising the 58-70 amino acid sequence of Platelet Factor 4 (PF-4) residues.

β-Melanocyte Stimulating Hormone (MSH), human TFA, is a 22-residue peptide functioning as an endogenous agonist for the melanocortin-4 receptor (MC4-R) [1].

TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α.

Human Growth Hormone-Releasing Factor TFA, also known as Growth Hormone-Releasing Factor Human TFA, is a hypothalamic polypeptide that promotes the production and release of growth hormone (GH) through its interaction with the Growth Hormone-Releasing Hormone Receptor (GHRHR) on anterior pituitary cells [1].

Antibodies corresponding to beta-amyloid (4-10) are effective in vivo inhibitors of cytotoxicity, amyloid plaque formation and special memory disturbances in mice. This peptide does not elicit an inflammatory response.

Luteinizing hormone (LH), a heterodimeric glycoprotein hormone synthesized by the pituitary gland, serves vital functions in human reproductive processes.

ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat), the fragment spanning amino acids 3-24 of adrenocorticotropic hormone (ACTH), serves as a research tool in studying illnesses such as cancer, immune diseases, and cardiovascular disease [1].

Kisspeptin-10, human is an effective vasoconstrictor and inhibitor of angiogenesis.

(Des-His^6)-ACTH (1-24) (human, bovine, rat) is an adrenocorticotropic hormone (ACTH) analog. Produced by the anterior pituitary gland, ACTH is a polypeptide tropic hormone that regulates the production of cortisol and androgens [1].

Acetyl-ACTH (3-24) (human, bovine, rat), a segment derived from the proopiomelanocortin (POMC) peptide, functions as an agonist at the MC-1 receptor [1]. Encompassing adrenocorticotrophin (ACTH), a precursor to α-MSH, it illustrates its role within the spectrum of POMC peptides.

Stimulating -Melanocyte Stimulating Hormone (MSH), human TFA, is a 22 peptide and is an endogenous melanocortin-4 receptor.MC4 - R) agonists.

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers.

Parathyroid Hormone (1-34), human, biotinylated is a probe targeting the parathyroid hormone receptor, used to analyze parathyroid hormone-receptor interactions within living cells and to purify hormone-receptor complexes via affinity columns [1] [2].

Adrenocorticotropic Hormone (ACTH) (1-10), human, is a fragment of adrenocorticotropin hormone. It demonstrates weak α-melanocyte stimulating hormone (α-MSH) potency, which is only apparent at high doses (100 and 1000 nM).

ACTH (7-38) (human) is a fragment (7-38) of the full human adrenocorticotropic hormone (ACTH (1-39)), also known as corticotropin inhibitory peptide (CIP). It functions as an antagonist to the ACTH receptor and lacks corticosteroid activity [1].

Kisspeptin-10, human TFA, is a potent vasoconstrictor and angiogenesis inhibitor that also suppresses tumor metastasis through its interaction with the receptor GPR54. It is crucial for embryonic kidney development and promotes osteoblast differentiation through NFATc4-mediated BMP2 expression via the Kisspeptin-10/GPR54 signaling pathway [1].

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, is a selective and potent NK2 receptor (NK2R) agonist with prokinetic activity, making it valuable for researching smooth muscle contractions across various tissues through NK-2 receptor engagement [1][2][3].

(p-Iodo-Phe7)-ACTH (4-10), a derivative of adrenocorticotrophic hormone (ACTH) produced by the anterior pituitary gland, functions as a melanocortin (MC) receptor antagonist and effectively inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats [1].

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect in rat models [1][2].

(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent neurokinin-3 (NK3) antagonist [1].

Adrenocorticotropic Hormone (ACTH) (1-39), rat, is a potent melanocortin 2 (MC2) receptor agonist. Peptide fragments of ACTH (1-39) were formed during in vitro incubation with membrane preparations, isolated by high-pressure liquid chromatography, and characterized by determining their amino acid composition and NH2-terminal residue.

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist [1].

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

Adrenocorticotropic hormone (6-24) (ACTH (6-24) (human)) is a fragment of ACTH that acts as a competitive inhibitor of steroidogenesis prompted by full-length ACTH (1-39) and the shortened ACTH (5-24), with dissociation constants (Kd) of 13.4 nM and 3.4 nM, respectively. It also impedes the production of corticosterone and the accumulation of cyclic AMP (cAMP) triggered by human parathyroid hormone (hPTH 1-34) [1] [2].

Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in th

TNF-α (10-36), human (TFA) is a peptide of human TNF-α.

LH-RH (4-10), a heptapeptide, represents one of the primary degradation products of luteinising-hormone releasing hormone (LHRH), occurring through the pathways of the pituitary and hypothalamus. It is produced in macrophages and type II pneumocytes [1].

Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA), is a potent agonist of the melanocortin 2 receptor (MC2).

ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response.