aglycone

Teicoplanin aglycone is an antibacterial glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including Enterococcus faecalis and methicillin-resistant Staphylococcus aureus.

Daturataturin A aglycone is a natural product for research related to life sciences. The catalog number is TN3775 and the CAS number is 904665-71-0.

Doramectin aglycone is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysis product doramectin monosaccharide . Doramectin undergoes one round of acid-catalyzed hydrolysis to form doramectin monosaccharide which is then hydrolyzed again to remove the remaining saccharide unit and form doramectin aglycone.

Avermectin B1a aglycone is an aglycone form of the anthelmintic and insecticide avermectin B1a . It hyperpolarizes P. crassipes muscle fibers with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a aglycone decreases survival of C. elegans (MAC = 0.1 μM). In vivo, avermectin B1a aglycone prevents seizures induced by pentylenetetrazole in mice (ED50 = 43.9 mg/kg) without inducing deficits in rotarod performance.

Silvestrol aglycone (enantiomer) is a cyclopenta benzofuran core phenol.

Ivermectin B1a aglycone is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.

Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate. It impedes TNFα-stimulated NF-κB transcriptional activity, showing an IC 50 of 18.7 μM. At a concentration of 10 μM, aloenin aglycone decreases both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression in HepG2 cells exposed to 10 ng/mL TNFα [1].

Bredinin aglycone is a purine nucleotide analog that can be used to assay the efficiency of purine nucleotide analog catalysts .

Momordicoside I aglycone is a natural product

Plucheoside B aglycone is a natural product for research related to life sciences. The catalog number is TN5385 and the CAS number is 393862-19-6.

Oleuropein aglycone is a useful organic compound for research related to life sciences and the catalog number is T125057.

Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity.

7-Deoxyadriamycinol aglycone is an adriamycin metabolite.

Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus burnettiiOrg. Lett.21(5)1287-1291(2019)

Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.

Asiatic acid (Dammarolic acid) is the aglycone of asiaticoside used in wound healing with antioxidant, anti-inflammatory, and neuroprotective properties.

Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.

Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.

(-)-Arctigenin ((-)-Arctigenin) is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Arctigenin is a lignan found in certain plants of the Asteraceae, including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin.

Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.

Friedelinol is a pentacyclic trierpene plant as the free acid or the aglycone for many saponins. Friedelinol can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.

Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents.

Glycyrrhizin-6′′-methylester (compound 22), isolated from licorice root, serves as an aglycone to form methyl glucuronate. This process imparts a characteristic sweet and licorice flavor, devoid of bitterness, highlighting the crucial role of the free carboxyl group on the cone-bound glucuronic acid moiety in contributing to the compound's natural sweetness and licorice taste [1].

Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti

Glycyrrhizin-6′,6′′-dimethylester (compound 23), an aglycone derived from licorice saponin isolated from licorice root, plays a role in the production of methyl glucuronate. This process yields a comparable level of sweetness, licorice flavor, and bitterness [1].

Neopanaxadiol, an aglycone derived from protopanaxadiol type ginsenosides, exhibits promising potential for Alzheimer's disease research.

Tylogenin, a steroidal aglycone generated by acid hydrolysis from two seasonal glycosides occurring in Tylophora sylvatica, inhibits IgE-induced basophil mediator release for allergic reactions. In the rabbit basophil-dependent serotonin release (BDSR) assay system, the inhibitory activity of tylogenin was significantly greater than that of its parent glycosides, tylophoroside and acetyltylophoroside, and that of dexamethasone. The activity of tylogenin was found to increase with the incubation time. In the human leukocyte-dependent histamine release test model, the glycosides had only a minimal activity. In contrast, tylogenin, with a geom mean IC50 = 49 microM, exerted a significantly greater potency than dexamethasone. These results suggest that tylogenin could represent a new class of antiallergic agents.

Mogroside III is a triterpenoid glycoside and a nonsugar sweetener. Mogroside III is transformed by human intestinal bacteria to release secondary glycoside mogroside IIA1 and aglycone mogrol.

1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be a novel anti-breast-cancer bone me

Penupogenin is a steroidal aglycone isolated from the roots of Cynanchum auriculatum.

Quillaic Acid is the major aglycone of the saponins in the Chilean indigenous tree Quillaja saponaria Mol.

Rebaudioside M is a natural non-calorie sweetener isolated from Stevia rebaudiana Bertoni,is a glycoside of the ent-kaurene diterpenoid aglycone.

1. Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect. 2. Ginsenoside Rh4 has cytotoxic activity and its aglycone against cancer cell lines.

Jurubidine is a type of cyclised aglycone from Jurubine.