ald-ph-amido-peg4-c2-acid

Ald-Ph-amido-PEG4-C2-acid is a noncleavable linker used in the development of antibody-drug conjugates (ADC).

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

Ald-Ph-NHS ester is a non-cleavable linker utilized in antibody-drug conjugation (ADC).

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs.

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and FGF21-receptor agonist, suitable for development as a potential treatment for T2DM.

2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a polyethylene glycol (PEG)-based linker designed for constructing PROTACs.

2-(Azido-PEG2-amido)-13-propandiol is a Polyethylene glycol (PEG)-based PROTAC linker used for synthesizing PROTACs[1].

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is a chemical compound comprising a cereblon (CRBN) ligand that functions as an E3 ubiquitin ligase, along with a linker. It is utilized to create the PROTAC MD-224[1].

Ald-Ph-PEG2-Boc is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized E3 ligase ligand-linker conjugate, incorporating the cereblon ligand from Pomalidomide and a linker used in PROTAC technology. It facilitates targeted protein degradation by modulating E3 ligase activity, thereby enabling the selective elimination of specific proteins of interest.

Ald-Ph-amido-PEG4-propargyl is a non-cleavable, 4-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker used in ADC synthesis[1].

NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based compound used in the synthesis of PROTACs [1].

Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker used in PROTAC synthesis [1].

Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) is an alkyl ether-based linker widely used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Ald-Ph-amido-PEG1-C2-Pfp ester is a non-cleavable 1-unit PEG linker used in antibody-drug conjugation (ADC) to link antibodies with drugs.

Ald-Ph-amido-PEG3-C-COOH is a noncleavable linker used in the development of antibody-drug conjugates (ADCs).

AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-derived PROTAC linker suitable for the synthesis of PROTACs [1].

Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Ald-Ph-PEG12-TFP ester is a PEG-based linker for PROTACs that connects two essential ligands, playing a crucial role in the formation of PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable, 4-unit PEG linker used in antibody-drug conjugation (ADC) to attach antibodies to drugs.

Ph-Bis(C1-N-(C2-NH-Boc)2) is a versatile alkyl chain-derived linker used in the synthesis of PROTACs [1].

Ald-Ph-amido-PEG3-C2-Pfp ester is a noncleavable antibody-drug conjugate (ADC) linker, classified as a polyethylene glycol (PEG) linker.

Ald-Ph-PEG2-NH-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-amido-PEG24-acid, a polyethylene glycol (PEG)-based linker, is utilized in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

Ald-Ph-PEG4-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the [ubiquitin-proteasome] system within cells.

4-Methyl-4-(methyldisulfanyl)pentanoic acid is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and is designed to be cleavable.

Cbz-N-amido-PEG20-acid is a PEG-based linker for PROTACs [proteolysis-targeting chimeras] that connects two critical ligands essential for the formation of PROTAC molecules, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker used in PROTAC synthesis [1].

Ald-Ph-amido-PEG2-C2-NHS ester is a non-cleavable, 2-unit PEG linker used in antibody-drug conjugation (ADC) for attaching antibodies to drugs.

Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative mainly used as a noncleavable ADC linker[1].

Tetrazine-Ph-acid is an alkyl chain-derived PROTAC linker utilized in PROTAC synthesis [1].

N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 is a polyethylene glycol (PEG)-based linker compound primarily used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Mal-amido-PEG2-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands to form PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Mal-amido-(CH2COOH)2, also known as compound 7a, is an intermediate compound that contains maleimidoethyl for use in hydrophilic ADC linker synthesis[1].

Ald-Ph-PEG5-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enables selective protein degradation through the ubiquitin-proteasome system within cells.

SMARCA2 4-ligand-Linker Conjugate-8 is an E3 ubiquitin ligase ligand-linker conjugate.

4-Boc-amino-22-dimethylbutyric acid is an alkyl ether-derived PROTAC linker, suitable for PROTAC synthesis.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Mal-amido-PEG24-acid is a PEG-based linker for PROTACs that joins two essential ligands, critical for the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-Bromobutylphosphonic acid is an alkyl chain-derived PROTAC linker used for the synthesis of PROTACs [1].

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl ether-based linker suitable for PROTAC synthesis [1].

Ald-Ph-amido-PEG1-C2-NHS ester is a non-cleavable 1-unit PEG linker used in antibody-drug conjugation (ADC) to link antibodies with drugs.

Mal-amido-PEG10-acid is a PEG-based linker used in PROTACs, facilitating the combination of two key ligands essential for PROTAC molecule formation. This linker aids in selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].