all trans retinoyl β d glucuronide

all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. It is rapidly converted to all-trans retinoic acid following in vitro or in vivo administration.

All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions.

6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) is a chromogenic substrate for β-glucuronidase and can be utilized in the histochemical analysis of β-glucuronidase activity.

Oroxylin A 7-O-β-d-glucuronide was a new alkaloid which found in the bulbs of Lycoris radiata.

all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) is an active metabolite of vitamin A.

Glycyrrhetic acid 3-O-β-D-glucuronide is a potent sweetener (relative sweetness to sucrose: x 941).

Trans-Caffeoyl-6-O-D-gluconic acid, a natural product, is isolated from the almost mature fruits of Evodia rutaecarpa (Juss.) Benth. [1].

Deferiprone O-β-D-glucuronide, a new orally active iron chelator, effectively reduces the iron burden in patients with β-thalassemia [1].

All-trans-Phytofluene (Phytofluene), a compound extractable from tomatoes, plays a crucial role in the isomerization of lycopene and phytoene within the same fruit.

(S)-Ibuprofen acyl-β-D-glucuronide ((S)-Ibuprofen glucuronide) serves as a crucial analytical tool in examining the metabolic pathways and pharmacokinetic profile of S-ibuprofen, a widely used non-steroidal anti-inflammatory drug. This compound is specifically an acylglucuronic acid metabolite of S-ibuprofen, synthesized primarily in the liver [1].

Tolmetin β-D-Glucuronide has reactive properties with human serum albumin, allowing identification of the binding site and reaction mechanism by tandem mass spectrometry.

Propofol β-D-glucuronide is a metabolite of propofol sulfate, a short-acting anesthetic agent. The metabolite is generated through the glucuronidation of propofol by uridine diphosphate glucuronosyltransferases, and propofol metabolism appears to occur more rapidly in women than in men. [1] [2]

(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol , which is a metabolite of propranolol. The apparent half-life of (±)-4-hydroxy propranolol β-D-glucuronide is similar to propranolol and 4-hydroxy propranolol. Propranolol is a β-adrenergic antagonist, and the active enantiomer, (S)-(-)-propranolol , has log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.

Naringenin-7-O-β-D-glucuronide, a metabolite of the flavonoid naringenin, is predominantly synthesized through the action of UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A3, UGT1A6, and UGT1A9.

Cyclobenzaprine b-D-glucuronide is a metabolite of Cyclobenzaprine, utilized in the treatment of diseases associated with Coronavirus (Coronavirus) infections. It also serves in studying the metabolic pathways of Cyclobenzaprine in the body and acts as a potential candidate for researching treatments targeting Coronavirus infections.

4-Methylumbelliferyl β-D-glucuronide is a useful organic compound for research related to life sciences. The catalog number is T65323 and the CAS number is 6160-80-1.

Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1 1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544(2019) 2.Reese, M.J., Savina, P.M., Generaux, G.T., et al.In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitorDrug Metab. Dispos.41(2)353-361(2013)

Dichloro-all-trans-retinone is a selective inhibitor for retinaldehyde dehydrogenase enzymes, thereby irreversibly inhibiting RALDH1, 2, and 3.

Naringenin-7-O-beta-D-glucuronide is a natural product

Perindopril acyl-β-D-glucuronide is a metabolite of the ACE inhibitor perindopril [1].

Isoscutellarein 8-O-β-D-glucuronide, a flavonoid antioxidant, can be isolated from the seeds of Theobroma grandiflorum [1] [2].

All-trans-13,14-Dihydroretinol, a metabolite of all-trans-retinoic acid, is synthesized through the enzymatic action of retinol saturase on all-trans-retinoic acid.

Ezetimibe-d4 Phenoxy ß-D-Glucuronide is a deuterated compound of Ezetimibe Phenoxy ß-D-Glucuronide. Ezetimibe Phenoxy ß-D-Glucuronide has a CAS number of 190448-57-8.

Quercetin 3-O-β-D-glucuronide-6″-methyl ester, a flavonoid, has been isolated from Atraphaxis spinosa L [1].

Eriodictyol 7-O-β-D-glucuronide ethyl ester is a natural product for research related to life sciences. The catalog number is TN5523 and the CAS number is 847025-48-3.

β-D-Glucuronide-pNP-carbonate is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin is a natural product for research related to life sciences. The catalog number is TN2871 and the CAS number is 349545-02-4.

Resveratrol-4'-O-D-Glucuronide has anti-fat accumulation properties, is metabolized by resveratrol, and can be used in metabolism-related studies.

Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide) exhibits antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells.

Luteolin-3-O-beta-D-glucuronide effectively inhibits nitrite production in macrophages.

Propofol-d17 β-D glucuronide is a deuterated compound of Propofol7 β-D glucuronide.

Naringenin 7-O-β-D-glucuronide methyl ester is a natural product for research related to life sciences. The catalog number is TN5524 and the CAS number is 1985597-72-5.

Raloxifene 6,4'-Bis-β-D-glucuronide, a metabolite of Raloxifene, acts as a selective antagonist of the estrogen receptor used for osteoporosis prevention.

all-trans-5,6-Epoxy Retinoic Acid (Product No. T36382; CAS No. 13100-69-1) is utilized in life sciences research.

Curcumin-β-D-glucuronide, a principal metabolite detected in hepatic tissue and portal blood following oral consumption of Curcumin, is utilized in colon cancer research [1] [2].

Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential utility in Alzheimer's disease research [1].

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a valuable organic compound for life sciences research. Its catalog number is T66976, and its CAS number is [147266-92-0].

Estriol 16α-(β-D-glucuronide), an endogenous metabolite found in urine, is utilized in pregnancy research [1] [2].

All-trans-Anhydro Retinol (Anhydrovitamin A) is a Vitamin A metabolite commonly employed in the synthesis of multivitamin preparations[1].

Estriol 3-β-D-glucuronide is a metabolite of estriol . It is formed from estriol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A10. Estriol 3-β-D-glucuronide binds to basolateral and canalicular liver plasma membranes with Kd values of 85 and 164 μM, respectively. It competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide and is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc).

Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2]

Ethyl-β-D-glucuronide-d5 is a deuterated compound of Ethyl-β-D-glucuronide. Ethyl-β-D-glucuronide has a CAS number of 17685-04-0. Ethyl glucuronide is an endogenous metabolite.

Wogonin 7-O-beta-D-glucuronide methyl ester, a natural product, is isolated from [Huanglian Jiedutang].

DiosMetin 7-O-β-D-Glucuronide, an antioxidant constituent found in the fruits of Luffa cylindrical, supplies antioxidant benefits when sponge gourds are consumed.

5-Hydroxy tryptophol β-D glucuronide-d4 is a deuterated compound of 5-Hydroxy tryptophol β-D glucuronide.

(2S)-Pinocembrin 7-O-[2''-O-(5'''-O-trans-cinnamoyl)-β-D-apiofuranosyl]-β-D-glucoside is a natural product for research related to life sciences. The catalog number is TN5509 and the CAS number is 773899-29-9.

Trans-Resveratrol-3-O-β-D-Glucuronide, an active metabolite of trans-resveratrol, inhibits the proliferation of various intestinal cancer cell lines. Additionally, this compound enhances pyruvate production in the liver [1] [2] [3].