angiotensin iii

Angiotensin III is an agonist of angiotensin 1 (AT1) and AT2 receptor.

[Val4] Angiotensin III is an angiotensin III peptide variant and a potent full agonist for Gαq and βarr2 signaling pathways, exhibiting pEC50 values of 8.31 and 8.44, respectively [1].

Angiotensin III, human, mouse (Angiotensin III, human, mouse(3TFA))(3TFA) is an endogenous angiotensin II receptor (AT2R) agonist(IC50s of 0.648 nM).

Angiotensin III, human, mouse (TFA) is an angiotensin.

Spinorphin TFA acts as an inhibitor for multiple enkephalin-degrading enzymes, including aminopeptidase (aminopeptidase), dipeptidyl aminopeptidase III (dipeptidyl aminopeptidase III), angiotensin-converting enzyme (angiotensin-converting enzyme), and enkephalinase (enkephalinase). It exhibits an antinociceptive effect [1].

Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.

Angiotensin II human TFA, a potent vasoconstrictor within the renin/angiotensin system, plays a pivotal role in human blood pressure regulation primarily through interactions with the G-protein-coupled receptors Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). It not only prompts sympathetic nervous stimulation, aldosterone biosynthesis, and renal effects but also fosters growth in vascular smooth muscle cells and boosts collagen type I and III synthesis in fibroblasts. This action results in the thickening of the vascular wall and myocardium, alongside fibrosis. Additionally, Angiotensin II human TFA triggers apoptosis and encourages capillary formation from endothelial cells through the LOX-1 dependent redox-sensitive pathway [1] [2] [3] [4].