antidopaminergic

Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).

Itopride hydrochloride (Ganaton) is an AChE and D2DR inhibitor.

Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action.

L 646462 is an antidopaminergic agent.

Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports of heart rhythm abnormalities and these led to 80 deaths. Other reported adverse effects are: headache, diarrhea, abdominal pain, nausea, constipation. Cisapride for animals has been found helpful in some cases of megaesophagus and is a common treatment for feline megacolon. Clarithromycin, erythromycin, and troleandomycin markedly inhibit the metabolism of cisapride. Concurrent administration of certain anticholinergic compounds, such as belladonna alkaloids and dicyclomine, would be e......

Savoxepin mesylate, a tetracyclic cyano-dibenzoxepino-azepine derivative, has potent antidopaminergic activity.

Clebopride is antidopaminergic. Clebopride also has an effect of antiemetic.

Citatepine is a tetracyclic dopamine antagonist acting strongly antidopaminergic opposed to antiserotonergic. Some anticholinergic activity.