apixaban 13c,d3

Apixaban 13CD3 (BMS-562247-01 13CD3) is a deuterium-labeled Apixaban. Apixaban is a reversible inhibitor of Factor Xa (Ki: 0.08 nM and 0.17 nM in human and rabbit).

3-O-Methyldopa-d3 is a deuterated compound of 3-O-Methyldopa. 3-O-Methyldopa has a CAS number of 300-48-1.

4,6-Dichloro-N-(methyl-d3)-3-pyridazinecarboxamide is a deuterated compound of 4,6-Dichloro-N-(methyl)-3-pyridazinecarboxamide. 4,6-Dichloro-N-(methyl)-3-pyridazinecarboxamide has a CAS number of 1609394-78-6.

Alosetron-13C-d3 the 13C and deuterated compound of Alosetron. Alosetron has a CAS number of 122852-42-0. Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.

trans-Hydroxy Loxoprofen-13C-d3 (Mixture of Diastereomers) the 13C and deuterated compound of trans-Hydroxy Loxoprofen. trans-Hydroxy Loxoprofen has a CAS number of 371753-19-4.

Vancomycin-13C-d3 the 13C and deuterated compound of Vancomycin. Vancomycin has a CAS number of 1404-90-6. Vancomycin is an antibiotic used to treat serious bacterial infections by stopping the growth of bacteria.

Avanafil-13C-d3 the 13C and deuterated compound of Avanafil. Avanafil has a CAS number of 330784-47-9. Avanafil is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.

Lercanidipine-13C-d3 HCl the 13C and deuterated compound of Lercanidipine HCl. Lercanidipine HCl has a CAS number of 132866-11-6. Lercanidipine is a calcium channel blocker of the dihydropyridine class.

Ondansetron-13C-d3 the 13C and deuterated compound of Ondansetron. Ondansetron has a CAS number of 99614-02-5. Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.

Nicergoline-13C-d3 the 13C and deuterated compound of Nicergoline. Nicergoline has a CAS number of 27848-84-6. Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins.

Formoterol-13C-d3 Hemifumarate the 13C and deuterated compound of Formoterol Hemifumarate. Formoterol Hemifumarate has a CAS number of 43229-80-7. Formoterol Hemifumarate, an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma.

β-Apo-13-carotenone D3 is the deuterium labeled β-Apo-13-carotenone. β-Apo-13-carotenone is an antagonist of RXRα.

13C-d3-AOH1996 is the 13C and deuterated compound of AOH1996. 13C-AOH1996 has a CAS number of 2089314-64-5. AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis.AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II.AOH1996 acts synergistically with DNA damaging agents to inhibit tumor cell growth. AOH1996 inhibits tumor cell growth by stabilizing the interaction between PCNA and RNA polymerase II, leading to proteasome-dependent rpb1 degradation and lethal DNA damage.AOH1996 acts synergistically with DNA damaging agents.

Sofosbuvir-13C-d3 is the 13C and deuterated compound of Sofosbuvir. Sofosbuvir has a CAS number of 1190307-88-0. Sofosbuvir is a uridine monophosphate analog inhibitor of hepatitis C virus (HCV) polymerase NS5B that is used as an antiviral agent in the treatment of chronic hepatitis C.

Taltirelin-13C-d3 is the 13C and deuterated compound of Taltirelin. Taltirelin has a CAS number of 103300-74-9. Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].

Methylcobalamin-13C-d3 is the 13C and deuterated compound of Methylcobalamin. Methylcobalamin has a CAS number of 13422-55-4. Methylcobalamin is one active form of vitamin B12 which can directly participate in homocysteine metabolism. It is used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis.

Levomefolic Acid-13C-d3 the 13C and deuterated compound of Levomefolic Acid. Levomefolic Acid has a CAS number of 31690-09-2. Levomefolinic acid is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency

Mycophenolic acid-13C-d3 the 13C and deuterated compound of Mycophenolic acid. Mycophenolic acid has a CAS number of 24280-93-1. Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Moxifloxacin-13C-d3 the 13C and deuterated compound of Moxifloxacin. Moxifloxacin has a CAS number of 151096-09-2. Moxifloxacin is a fourth-generation fluoroquinolone that has been shown to be effective against Gram-positive, Gram-negative, and atypical strains, as well as multi-drug resistant Streptococcus pneumoniae.

3-Methyl-d3-butyric-3,4,4,4-d4 Acid is a deuterated compound of 3-Methyl-butyric Acid. 3-Methyl-butyric Acid has a CAS number of 503-74-2. 3-Methylbutanoic acid is a naturally occurring aroma compound found in Bartlett pear brandies, vanilla beans, rape-honey, and banana.

Tadalafil-13C-d3 the 13C and deuterated compound of Tadalafil. Tadalafil has a CAS number of 171596-29-5. Tadalafil is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.

PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor.

Primaquine-13C-d3 is the 13C and deuterated compound of Primaquine. Primaquine has a CAS number of 90-34-6. Primaquine is the generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the potent gametocytocide in falciparum malaria.

Trelagliptin-13C-d3 is the 13C and deuterated compound of Trelagliptin. Trelagliptin has a CAS number of 865759-25-7. Trelagliptin is a highly specific and long-acting DPP-4 inhibitor.

cis-Clopidogrel-MP-13C-d3 Derivative is the 13C and deuterated compound of cis-Clopidogrel-MP Derivative.

DL-4-Hydroxy-3-methoxymandelic-d3 acid is a deuterated compound of DL-4-Hydroxy-3-methoxymandelic acid.

13-cis Acitretin D3 (Isoacitretin D3) is a deuterium-labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin is a second-generation, systemic retinoid.

Ritonavir-13C-d3 the 13C and deuterated compound of Ritonavir. Ritonavir has a CAS number of 155213-67-5. Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450.

Rifampicin-13C-d3 the 13C and deuterated compound of Rifampicin. Rifampicin has a CAS number of 13292-46-1. Rifampicin is an antibacterial drug of the class of rifamycin.

Lincomycin-13C-d3 the 13C and deuterated compound of Lincomycin. Lincomycin has a CAS number of 7179-49-9. Lincomycin hydrochloride is an antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Regorafenib-13C-d3 the 13C and deuterated compound of Regorafenib. Regorafenib has a CAS number of 755037-03-7. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor (IC50s: 1.5 2.5 4.2 7 13 22 nM for RET C-RAF VEGFR2 c-Kit VEGFR1 PDGFRβ).

Clindamycin-13C-d3 the 13C and deuterated compound of Clindamycin. Clindamycin has a CAS number of 18323-44-9. Clindamycin dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. Clindamycin is a semisynthetic broad-spectrum antibiotic produced by chemical modification of the parent compound lincomycin.

Azithromycin-13C-d3 the 13C and deuterated compound of Azithromycin. Azithromycin has a CAS number of 83905-01-5. Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

Homovanillic Acid-13C-d3 the 13C and deuterated compound of Homovanillic Acid. Homovanillic Acid has a CAS number of 306-08-1. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Prasugrel Metabolite Derivative-13C-d3 is the 13C and deuterated compound of Prasugrel Metabolite Derivative.

Binimetinib Isomer Impurity-13C-d3 is the 13C and deuterated compound of Binimetinib Isomer Impurity.

(S)-Alogliptin Benzoate Salt-13C-d3 is the 13C and deuterated compound of (S)-Alogliptin Benzoate Salt.

Prucalopride-13C-d3 is the 13C and deuterated compound of Prucalopride. Prucalopride has a CAS number of 179474-81-8. Prucalopride is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes.

rac-Hesperetin-13C-d3 the 13C and deuterated compound of rac-Hesperetin. rac-Hesperetin has a CAS number of 69097-99-0. (Rac)-Hesperetin is the racemate form of of Hesperetin. Hesperetin is a natural flavanone compound, and it exhibits potent inhibitory effects against human UGT activity, making it a broad-spectrum inhibitor. Furthermore, Hesperetin induces apoptosis through the activation of p38 MAPK.

Sildenafil-13C-d3 the 13C and deuterated compound of Sildenafil. Sildenafil has a CAS number of 139755-83-2. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).

Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E Z)-Sulindac sulfide can be used for researching Alzheimer’s disease [1].

3-Hydroxy agomelatine D3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).

Regorafenib-13C-d3 N-Oxide the 13C and deuterated compound of Regorafenib N-Oxide. Regorafenib N-Oxide has a CAS number of 835621-11-9. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1 2 3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13 4.2 46, 1.5, 22, 7, and 2.5 nM).

Exemestane-13C-d3 the 13C and deuterated compound of Exemestane. Exemestane has a CAS number of 107868-30-4. Exemestane is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.

Lamotrigine-13C-d3 the 13C and deuterated compound of Lamotrigine. Lamotrigine has a CAS number of 84057-84-1. Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.

Gemcitabine EP Impurity C-13C-15N2 is the 13C and 15N labeled compound of Gemcitabine EP Impurity C.

Clevidipine Impurity 24-13C-d3 the 13C and deuterated compound of Clevidipine Impurity 24.

Binimetinib-13C-d3 is the 13C and deuterated compound of Binimetinib. Binimetinib has a CAS number of 606143-89-9. Binimetinib (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay.