apn c3 peg4 alkyne

APN-C3-PEG4-alkyne is a PEG-based linker for PROTACs, joining two essential ligands critical for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

Chloroacetamido-C-PEG3-C3-NHBoc is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs).

Cl-C6-PEG4-C3-COOH, a PROTAC linker, is a suitable component for synthesizing chloroalkane-containing PROTACs (HaloPROTACs).

Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG4-based linker used in PROTACs synthesis [1].

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

Dde Biotin-PEG4-alkyne is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by connecting two essential ligands, and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker used in PROTAC synthesis [1].

APN-PEG4-tetrazine, a cleavable ADC linker compound composed of four PEG units, is specifically designed for the synthesis of antibody-drug conjugates (ADCs) [1].

TAMRA-PEG4-Alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG4-amino-t-Bu-DADPS-C3-alkyne serves as a PEG-based linker for PROTAC synthesis [1].

NHS-PEG4-(m-PEG12)3-ester is a polyethylene glycol (PEG)-based linker used for PROTAC synthesis [1].

Dde Biotin-PEG4-TAMRA-PEG4 Alkyne, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 is a polyethylene glycol (PEG)-based linker compound primarily used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-C3-PEG4-amine is a PEG-based linker for PROTACs that joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

APN-PEG4-DBCO is a cleavable linker for antibody-drug conjugates (ADCs), consisting of a four-unit PEG and a DBCO moiety, used in ADC synthesis[1].

DBCO-(PEG)3-VC-PAB-MMAE is a chemical compound where monomethyl auristatin E (MMAE), a potent tubulin inhibitor used as a toxin payload in antibody-drug conjugates, is conjugated via a DBCO-(PEG)3-vc-PAB linker.

Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived cereblon ligand used to recruit CRBN protein, and can be linked via a linker to a ligand for protein to create PROTACs [for protein degradation].

PC Alkyne-PEG4-NHS ester is a cleavable 4-unit polyethylene glycol (PEG) linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

PTAD-PEG4-alkyne is a four-unit polyethylene glycol (PEG) linker compound, employed in the synthesis of antibody-drug conjugates (ADCs)[1]. It is cleavable and serves as a connecting structure between the antibody and the drug, facilitating targeted drug delivery.

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-derived PROTAC linker used in the synthesis of PROTACs[1].

APN-PEG4-PFP is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG4-PC-PEG4-alkyne is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker used in the synthesis of PROTACs[1].

Carboxyrhodamine 110-PEG4-alkyne is a polyethylene glycol (PEG) derived linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Alkyne-PEG4-maleimide is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Biotin-PEG4-amide-Alkyne is a polyethylene glycol (PEG)-based linker primarily used for synthesizing PROTACs[1].

(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-derived PROTAC linker applicable for the synthesis of PROTACs [1].

DBCO-C3-PEG4-NH-Boc is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Lenalidomide 4'-alkyl-C3-azide (compound 4a), a chemically modified version of the orally active immunomodulator lenalidomide, is engineered for the synthesis of PROTACs. This compound, serving as a ligand for the ubiquitin E3 ligase cereblon (CRBN), integrates an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups [1].

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

NHS-PEG4-(m-PEG4)3-ester is a PEG-based PROTAC linker used for synthesizing PROTACs [1].

APN-PEG4-BCN is a cleavable, four-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

BCN-PEG4-alkyne is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG4-4-nitrophenyl carbonate, a PEG-derived PROTAC linker, enables the synthesis of PROTACs[1].

APN-C3-PEG4-azide is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands vital for PROTAC molecule formation. This linker supports selective protein degradation via the cell's ubiquitin-proteasome system.

Alkyne-PEG4-SS-PEG4-alkyne is an eight-unit polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) synthesis, enabling cleavage and controlled drug release under specific conditions [1].

N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a polyethylene glycol (PEG)-based linker used in PROTAC synthesis [1].

DBCO-PEG4-alkyne is a four-unit PEG linker with non-cleavable properties, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].

APN-PEG4-Amine (hydrochloride) is a cleavable four-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

APN-C3-NH-Boc is a alkyl ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG4-alkyne is a biotin-labeled, polyethylene glycol-based (PEG-based) PROTAC linker utilized in PROTAC synthesis.