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apto-253

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    5
    TargetMol | Activity
APTO-253
T10352916151-99-0
APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the KLF4 tumor suppressor.
  • $36
In Stock
Size
QTY
APTO-253 HCl
T702731691221-67-6
APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
  • $1,520
1-2 weeks
Size
QTY
APTO-253 isomer
T707061422826-80-9
APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
  • $1,520
6-8 weeks
Size
QTY
Flufenacet
T71948142459-58-3
Flufenacet is a herbicide, inhibiting very-long-chain fatty acid elongase (VLCFAE) synthesis.
  • $1,520
6-8 weeks
Size
QTY
L-162782
T70272169281-92-9
L-162782 is a nonpeptide agonist of angiotensin AT1 receptor.
  • $1,820
8-10 weeks
Size
QTY