ar-13324 m-1 metabolite

AR-M 1896 Acetate is the selective agonist of GalR2.

AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.

Abiraterone Metabolite 1, a 5β-reduced derivative of abiraterone, acts by inhibiting CYP17A1, thereby blocking androgen synthesis and extending survival in prostate cancer patients.

AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.

PROTAC AR-V7 degrader-1 (Compound 6) is an orally bioavailable, potent, and selective degrader targeting the androgen receptor (AR) variant V7, achieving degradation with a DC50 of 0.32 µM by directing the VHL E3 ligase to the AR DNA-binding domain (DBD). It demonstrates efficacy in the 22Rv1 cell line expressing AR-V7, with an EC50 of 0.88 µM [1].

β2AR/M-receptor agonist-1 (example 131), a muscarinic antagonist and β2 adrenoceptor agonist (MABA), exhibits dual potency towards β2 adrenoceptor and muscarinic receptor. It demonstrates a significant affinity for the β2 adrenoceptor, indicated by an EC50 value of 9.2 nM, and for the muscarinic receptor with a Ki value of 30.2 nM. Furthermore, its MABA activity is highlighted by an EC50 value of 4.0 nM [1].

A1/A3 AR antagonist 1 (Compound 10) is a potent, dual adenosine 1 (A1) and adenosine 3 (A3) receptor antagonist that acts on human A1 (Ki: 37.6 nM), human A3 (Ki: 25.4 nM) and rat A1 (Ki: 1.47 nM). 1 Can be used to study renal failure, inflammatory lung disease and Alzheimer's disease.

A2A/A1 AR antagonist-1 (compound 1a) has the potential for ischemic stroke research which is potent A 2A /A 1 AR dual antagonist with Ki s of 5.58 and 24.2 nM, respectively [1].

1,3-Butanediol, 1-(m-chlorophenyl)-4,4,4-trifluoro-3-trifluoromethyl- is a bioactive chemical.

Phenol, m-(1-methyl-3-propyl-3-pyrrolidinyl)-, butyrate is a bioactive chemical.

1-(b-D-Xylofuranosyl)-N6-(m-trifluoromethyl benzyl) adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside, Fluoro-modified nucleoside.

m-(1-Methylbutyl)phenyl methylcarbamate is a bioactive chemical.

Benzoic acid, m-(2-(p-bromophenyl)-5-methylpyrrol-1-yl)- is a bioactive chemical.

β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).

m-Dioxane, 5-isopropyl-5-(1-methoxyethyl)-2-methyl-, (E)- is a bioactive chemical.

AR-13324 analog mesylate is an inhibitor of Rho-kinase and a norepinephrine transporter and reduces intraocular pressure in normotensive monkey eyes.

Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)-, compd. with 2-amino-2-methyl-1-propanol (1:1) is a bioactive chemical.

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(1-methyl-2-piperidino)ethyl- is a bioactive chemical.

Lopinavir Metabolite M-1, an active metabolite derived from Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM. Additionally, in vitro studies have revealed notable antiviral properties associated with Lopinavir Metabolite M-1.

Phenol, m-(1-methyl-3-propyl-3-pyrrolidinyl)-, acetate is a bioactive chemical.

Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)- is a bioactive chemical.

Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)-, compd. with 2-aminoethanol (1:1) is a bioactive chemical.

Phenol, m-(2,3-dipropyl-1-methyl-3-pyrrolidinyl)- is a bioactive chemical.

Tofacitinib metabolite-1, a derivative of Tofacitinib, which is a JAK inhibitor, is employed in studies focused on the pharmacokinetics and metabolism of tofacitinib[1][2].

m-Anisidine, 4-((1-methylheptyl)oxy)-, hydrochloride is a bioactive chemical.

Ar-V7-IN-1 is a highly potent inhibitor specifically targeting Ar-V7, a splice variant of the androgen receptor that exhibits hormone-independent behavior. Its development shows promise for researching various indications, notably cancers such as prostate cancer[1].

Phenol, m-(2,3-dipropyl-1-methyl-3-pyrrolidinyl)-, acetate is a bioactive chemical.

m-(1-Pyrrolidinyl)phenol is a bioactive chemical.

Carbanilic acid, m-((hexyloxy)methyl)-, 2-(hexahydro-1H-azepin-1-yl)ethyl ester, hydrochloride is a bioactive chemical.

Phenol, m-(2-ethyl-1-methyl-3-propyl-3-pyrrolidinyl)-, acetate is a bioactive chemical.

4,4,4-Trifluoro-1-(m-tolyl)butane-1,3-dione is a useful organic compound for research related to life sciences. The catalog number is T66381 and the CAS number is 53764-99-1.

Phenol, m-(2-(N-ethylphenethylamino)ethyl)-, fumarate (1:1) is a bioactive chemical.

Phenol, m-(2-ethyl-1-methyl-3-propyl-3-pyrrolidinyl)- is a bioactive chemical.

m-((4-((4-(Bis(2-hydroxyethyl)amino)phenyl)azo)-1-naphthyl)azo)benzenesulphonic acid is a bioactive chemical.

Phenol, m-(1-methyl-3-neopentyl-3-pyrrolidinyl)- is a bioactive chemical.

Carbanilic acid, m-((pentyloxy)methyl)-, 2-(1-pyrrolidinyl)ethyl ester, hydrochloride is a bioactive chemical.

Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin.

Benzoic acid, m-(1-phenylureido)- is a bioactive chemical.

Phenol, m-(1-methyl-3-(2-methylbutyl)-3-pyrrolidinyl)- is a bioactive chemical.

Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)-, compd. with morpholine (1:1) is a bioactive chemical.

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(2-(1-pyrrolidinyl)ethyl)-, hydrochloride is a bioactive chemical.

Carbanilic acid, m-((pentyloxy)methyl)-, 2-(hexahydro-1H-azepin-1-yl)ethyl ester, hydrochloride is a bioactive chemical.

1-(b-D-Xylofuranosyl)-N6-(m-methoxybenzyl) adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside.

Phenol, m-(1-methyl-3-propionyl-3-pyrrolidinyl)-, hydrochloride is a bioactive chemical.

PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antagonizing AR-NTD, this compound effectively degrades AR-V7 protein and triggers apoptosis in prostate cancer (PC) cells, with degradation efficiencies in VCaP cells recorded at 62.2% (1 μM) and 71.1% (5 μM), as noted in reference [1].

Phenol, m-(1-(p-hydroxyphenethyl)-3-isopropyl-3-pyrrolidinyl)-, hydrochloride, hydrate is a bioactive chemical.

Carbanilic acid, m-((hexyloxy)methyl)-, 2-(1-pyrrolidinyl)ethyl ester, hydrochloride is a bioactive chemical.

Benzoic acid, m-(2,5-dimethylpyrrol-1-yl)- is a bioactive chemical.

Compound 23, designated as A2A/A3 AR antagonist-1, is a dual fluorescent ligand targeting A2A and A3 adenosine receptors (AR), exhibiting dissociation constants (Ki) of 90 nM for hA2A AR and 31.8 nM for hA3 AR, respectively [1].

1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine , Clofarabine , Fludarabine phosphate and Vidarabine [1] .