azido peg3 ch2co2me

Azido-PEG3-CH2CO2Me, a PEG-based linker for PROTACs, joins two essential ligands crucial for PROTAC molecule formation. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker used in the synthesis of MT802 and SJF620, which are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively [1].

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Azido-PEG3-azide is a PEG-based PROTAC linker utilized in PROTAC synthesis.

PROTAC ERRα ligand 2 is an inverse agonist for the estrogen-related receptor α (ERRα) with an IC50 of 5.67 nM.

TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.

Hydroxy-PEG4-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and can also be employed in the synthesis of PROTAC.

Compound 72-1, also known as BCL-xL BCL-2 ligand 1, serves as a ligand for BCL-xL and BCL-2 proteins. It can be tethered to an E3 ligase via a linker, facilitating the formation of PROTACs [1] [2].

VEGFR-2-IN-39 (PROTAC-5), a PROTAC that targets VEGFR-2 with an IC 50 of 208.6 nM, demonstrates low toxicity. It effectively inhibits the proliferation of EA.hy926, a type of HUVEC, in a concentration-dependent manner, achieving an IC 50 value of 38.65 µM [1].

PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.

PROTAC EGFR degrader 2 is a potent compound with an IC50 of 4.0 nM, demonstrating strong antiproliferative activity, and a DC50 of 36.51 nM, indicating robust EGFR degradation activity. It is suitable for synthesizing nitroreductase (NTR)-responsive PROTACs [1].

(R)-Azetidine-2-carboxylic acid, with catalog number T66331 and CAS number 7729-30-8, is a valuable organic compound for life sciences research.

Bis (2-bromoethyl) ether, an alkyl chain-derived PROTAC linker, facilitates the synthesis of PROTACs.

GID4 Ligand 2 (compound 67) is a selective binder for GID4 with an IC50 of 18.9 μM and a Kd of 17 μM, and can be used for the synthesis of PROTACs [1].

Azido-PEG3-methyl ester is a polyethylene glycol (PEG)-derived linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

DBCO-(PEG2-Val-Cit-PAB)2 is a dual-cleavable linker used in antibody-drug conjugates (ADCs).

N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs [1].

Azido-PEG3-S-PEG4-propargyl is a polyethylene glycol (PEG)-based linker containing azide and propargyl groups, designed specifically for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation (ADC).

N-(Azido-PEG3)-N-bis(PEG4-Boc) is a polyethylene glycol (PEG) derivative designed specifically as a linker for PROteolysis TArgeting Chimeras (PROTACs)[1].

PROTAC BET-binding moiety 2 is an inhibitor of the BET bromodomain.

PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].

Azido-PEG3-aminoacetic acid-NHS ester is a PEGylation-based linker for the synthesis of PROTACs[1], providing a versatile and efficient approach.

Azido-PEG3-phosphonic acid ethyl ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker.

N-(Azido-PEG3)-N-Boc-PEG3-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

PROTAC MDM2 Degrader-2, designed using PROTAC technology, functions as a MDM2 degrader. It consists of a highly potent MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase, facilitating the degradation of MDM2[1].

N-(Azido-PEG3)-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based linker that incorporates an azido group and two PEG3-acid moieties, widely applicable in the synthesis of proteolysis targeting chimeras (PROTACs) for the selective degradation of target proteins[1].

The PEG-based PROTAC linker, N-(Azido-PEG2)-N-Boc-PEG3-NHS ester, is suitable for the synthesis of PROTACs[1].

Azido-PEG3-maleimide is a PEG-based PROTAC linker used primarily for the synthesis of PROTACs[1] and also functions as a cleavable 3-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].

Azido-PEG3-amide-C3-triethoxysilane is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1].

(2-Pyridyldithio)-PEG4-alcohol, a PEG-based PROTAC linker, is used for the synthesis of PROTACs[1].

N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

Azido-PEG3-SS-PEG3-azide, a polyethylene glycol (PEG) based linker, is commonly used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

SNIPER(TACC3)-2 targets TACC3 protein degradation via the ubiquitin-proteasome pathway. It induces cancer cell death.

RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor that effectively blocks RIP2-dependent pro-inflammatory signaling and regulates RIP2 kinase activity in autoinflammatory diseases [1].

PROTAC VEGFR-2 degrader-2 (PROTAC-4), a specific degrader of VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and low anti-proliferative activity towards EA.hy926 cells (IC50 > 100 μM) [1].

PROTAC VEGFR-2 Degrader-1 (PROTAC-1), a specific degrader of PROTAC VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and exhibits low anti-proliferative effects on EA.hy926 cells (IC50 > 100 μM) [1].

PROTAC STAT3 degrader-2 is a selective and effective PROTAC degrader of the STAT3 protein, exhibiting a DC50 of 3.54 μM in Molm-16 cells. It holds potential for cancer research [1].

PROTAC BRD4 Ligand-2 Hydrochloride serves as a ligand targeting the BRD4 protein, specifically designed for use with PROTAC CFT-2718.

Mpro ligand 2 (Compound 8) serves as the target protein ligand for PROTAC SARS-CoV-2 Mpro degrader-3.