BCL2-IN-1 is a potent Bcl-2 inhibitor (Ki <0.01 nM).

CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells. Additionally, it inhibits Bcl-2 and promotes apoptosis in A549 lung cancer cells [1].

Hymeglusin, A selective 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) synthase 1 inhibitor, is also an antibiotic that reduces the expression level of BCL2 in HL-60 and KG-1 cells and can be used to study leukemia.

(S)-(-)-Perillic acid, a terpenoid plant extract, exhibits antimicrobial and anticancer properties. This compound promotes cell apoptosis and cell cycle arrest while enhancing the levels of proteins such as Bax, Bcl2, p21, and caspase-3. It holds potential for research in cancer and infection treatments [1] [2] [3].