bcl2-like 12

Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin’s lymphoma.

MCL-1 BCL-2-IN-4 is a selective and potent dual inhibitor of Mcl-1 and Bcl-2.

Bcl-2-IN-16 is an inhibitor of Bcl-2 (B-cell lymphoma 2) [1].

Bcl-2-IN-9 is a novel, pro-apoptotic, low cytotoxic Bcl-2 inhibitor (IC50: 2.9 μM) that downregulates Bcl-2 expression, induces apoptosis in cancer cells, and exhibits high selectivity for leukemia cells.

SARS-CoV-2-IN-12, a potent inhibitor of the SARS-CoV-2-related 3C-like protease (K_i=32.1 pM), plays a crucial role in preventing SARS-CoV-2 viral replication, showcasing potential significance in COVID-19 research.

Bcl-2-IN-4, an orally active and selective inhibitor of Bcl-2, demonstrates potent efficacy with an IC50 value of 1.5 nM and exhibits more than 200-fold selectivity over Bcl-xL (IC50 of 411 nM). Additionally, it effectively inhibits the proliferation of RS4;11 cells, achieving an IC50 of 2.7 nM.

VEGFR-2-IN-12 (compound 6g), a 2-oxoquinoxalinyl-1,2,4-triazole, is a potent inhibitor of VEGFR-2 with an IC50 of 0.037 μM and demonstrates anti-tumor effects.

Bcl-2 Mcl-1-IN-3 is a Bcl-2 Mcl-1 inhibitor, targeting Mcl-1 (Ki: 0.14 μM) and Bcl-2 (Ki: 0.23 μM), suitable for cancer research.

Bcl-2 Mcl-1-IN-2 is an inhibitor of Bcl-2 [Ki: 4.70 μM] and Mcl-1 [Ki: 0.88 μM], suitable for use in cancer research.

11R,12-Dihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN2593 and the CAS number is 62574-30-5.

Bombinin-like peptide 2, an antimicrobial peptide sourced from the skin secretions of the Asian toad (Bombina orientalis), exhibits antimicrobial properties [1].

Compound 72-1, also known as BCL-xL BCL-2 ligand 1, serves as a ligand for BCL-xL and BCL-2 proteins. It can be tethered to an E3 ligase via a linker, facilitating the formation of PROTACs [1] [2].

MCL-1 BCL-2-IN-2 is a potent and selective dual inhibitor of Bcl-2 and Mcl-1.

Bcl-2-IN-7 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2), which can downregulate the expression of Bcl-2, increase the expression of p53, Bax, caspase-7 mRNA, and induce cell cycle arrest and apoptosis in MCF-7 cells of breast cancer. Bcl2-IN-7 showed good antitumor activity against MCF-7 cells (IC50: 20.17 μM), LoVo cells (IC50: 22.64 μM), HepG2 cells (IC50: 45.57 μM) and A549 cells (IC50: 51.50 μM).

PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.

COX-2-IN-12 (compound 3b) is a potent and selective COX-2 inhibitor with an IC50 of 19.98 μM, demonstrating anti-inflammatory properties and safety in in-vivo acute toxicity studies [1].

2-(2-Acetoxy-12-hydroxytridecyl)-4,6-dihydroxybenz is a useful organic compound for research related to life sciences. The catalog number is T126038 and the CAS number is 133361-20-3.

Bcl-2-IN-6 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2) that downregulates Bcl-2 expression and increases the expression of p53, Bax, and caspase-7 mRNA. bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. bcl-2-IN-7 acts on MCF-7 cells ( Bcl2-IN-7 showed good antitumor effects on MCF-7 cells (IC50: 20.91 μM), LoVo cells (IC50: 22.30 μM), HepG2 cells (IC50: 42.29 μM) and A549 cells (IC50: 48.00 μM).

Bcl-2-IN-12 (Compound 1) is a potent Bcl-2 inhibitor with an IC50 value of 6 nM, used in cancer research [1].

Bcl-2-IN-14 (Compound 13c), a BCL-2 inhibitor with an inhibitory concentration (IC50) of 0.471 μM, is applicable in cancer research [1].

Bcl-2-IN-17, a Bcl2 inhibitor, is utilized for researching diseases associated with the Bcl anti-apoptotic protein [1].

Bcl-2-IN-15 (Compound 13d) is a Bcl-2 inhibitor with an IC50 of 363 nM that impedes the proliferation of the NCI leukemia cancer cell line [1].

MCL-1 BCL-2-IN-3 is a selective and potent dual inhibitor of Mcl-1 and Bcl-2, with IC50 values of 5.95 and 4.78 μM, respectively.

MCL-1 BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2, with IC50 values of 4.45 μM and 3.18 μM, respectively [1].

Bcl-2-IN-5 is a potent BCL-2 inhibitor with inhibitory concentrations (IC50) of 0.12 nM, 0.14 nM, and 0.22 nM against wild type Bcl-2, Bcl-2 D103Y, and Bcl-2 G101V, respectively. It also suppresses cell growth in Bcl 2-G101V knock-in [RS4;11] cells, with IC50 values of 0.2 nM and 0.44 nM.

Bcl-2-IN-8 is a potent anti-cancer agent that exhibits anti-proliferative effects on both drug-sensitive and drug-resistant cancer cells, inhibits cell migration in a dose-dependent manner, blocks the cell cycle in the G1 phase, and induces apoptosis. Bcl-2-IN-8 has shown research potential in [triple-negative breast cancer].

SARS-CoV-2 Mpro-IN-12 (compound D026) is an inhibitor of the main protease (Mpro) of SARS-CoV-2, demonstrating antiviral properties [1].

(Rac)-Phorbol-12-(2-methylbutyrate), a natural product, can be isolated from croton oil [1].

Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor with an IC50 of 0.9 nM and minimal inhibition against Bcl-xl (IC50 > 1000 nM). It is used in cancer research related to Bcl-2 family protein overexpression, particularly in hematologic malignancies like acute lymphoid leukemia, while minimizing the risk of side effects such as thrombocytopenia [1] by sparing Bcl-xl.

Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].

Bcl-2-IN-13, a potent Bcl-2 inhibitor with an IC50 of 17 nM, shows promise for cancer research applications [1].

Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL, displaying an IC50 value of 0.034 nM against Bcl-2 and 43 nM against Bcl-xL, demonstrating over 1000-fold selectivity for Bcl-2 compared to Bcl-xL.

5-(2-Acetoxy-12-hydroxytridecyl)-1,3-benzenediol is a useful organic compound for research related to life sciences. The catalog number is T126037 and the CAS number is 133361-21-4.

Bcl-2 Mcl-1-IN-1 is an inhibitor of Bcl-2 (Ki: 4.53 μM) and Mcl-1 (Ki: 1.19 μM), and can be used in cancer research.

11S,12-Dihydroxyspirovetiv-1(10)-en-2-one is a natural product for research related to life sciences. The catalog number is TN2594 and the CAS number is 62623-86-3.

1-Palmitoyl-2-12-PAHSA-3-oleoyl-sn-glycerol, an endogenous triacylglycerol, comprises palmitic acid (at the sn-1 position), the fatty acid ester of hydroxy fatty acids (FAHFA), 12-PAHSA (at the sn-2 position), and oleic acid (at the sn-3 position). Identified in the lipid extract of mouse adipose tissue, this triacylglycerol demonstrates that levels of FAHFA-containing triacylglycerols are over 100-fold higher than those of non-esterified FAHFAs, suggesting their role as intracellular storage reservoirs for FAHFAs.