benzothiazole

FAAH inhibitor 1 (Benzothiazole analog 3) is a potent FAAH inhibitor with an IC50 of 18 nM.

Phenyl-benzothiazole (2-(4-Aminophenyl)-6-methylbenzothiazole) is an azole for proteomics research.

Compound Fr12380 is a useful organic compound for research related to life sciences. The catalog number is Fr12380 and the CAS number is 3622-35-3.

N-(m-PEG4)-3,3-Dimethyl-3H-indole-N'-(acid-PEG3)-benzothiazole is a PEG-based PROTAC linker suitable for synthesizing PROTACs [1].

Phenyl-benzothiazole HCl is an azole for proteomics research.

Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine ((4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone) is a raw material for biosynthesis and can be used to synthesize various compounds.

(R)-4,5,6,7-Tetrahydro-benzothiazole-2,6-diamine is a useful organic compound for research related to life sciences. The catalog number is T66622 and the CAS number is 106092-11-9.

N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a polyethylene glycol (PEG)-based linker used in the synthesis of PROteolysis TArgeting Chimeras (PROTACs) [1].

N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5 is a polyethylene glycol-based linker (PEG-PROTAC) suitable for PROTAC development through chemical synthesis [1].

N,N'-bis-(Acid-PEG3)-benzothiazole Cy5 is a polyethylene glycol (PEG)-derived PROTAC linker used in PROTAC synthesis [1].

Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine can be used to alter the lifespan of eukaryotic cells.

Other heterocyclic compound, intermediate and building block -electrophile

Other heterocyclic compound, intermediate and building block-electrophile

Morpholinylmercaptobenzothiazole is an aftereffect rapid vulcanization accelerator

2-Mercaptobenzothiazole (Captax) is an organosulfur compound. 2-Mercaptobenzothiazole is used in rubber vulcanization.

CGP 20376 is a benzothiazole compound, an anthelmintic, with dual dose-dependent modulation of in vitro effects on the respiratory burst of eosinophils and antifibrillatory properties.

BTA-188 is one of the most potent analogues of novel and orally active synthetic benzoxazole and benzothiazole derivatives with significant anti-rhinovirus activity.

Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain.

TbPTR1 inhibitor 2 is identified as a new development of improved pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic agents[1].

Phenylbenzothiazole-PEG4-OH (compound 1) shows therapeutic potential for spinal cord injury and may enhance spine formation [1].

(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole is a useful organic compound for research related to life sciences. The catalog number is T65668 and the CAS number is 106092-09-5.

Sodium 2-mercaptobenzothiazole is the sodium salt of mercaptobenzothiazole, and is used as a copper corrosion inhibitor.

5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole acts as a competitive inhibitor at the Qo site of the cytochrome bc1 complex (cytochrome c oxidoreductase) in Saccharomyces cerevisiae [1].

N,N-Dicyclohexyl-2-benzothiazolesulfenamide is a bioactive chemical.

CID1231538 is a potent GPR35 antagonist.

GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed.

WUN 73823, also known as N,N'-bis-(acid-PEG3)-Benzothiazole Cy5 is a PEG derivative containing a cyanine dye with excitation/emission maximum 649/667 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydophilic PEG spacer increases solubility in aqueous media. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg. Formulations containing riluzole have been explored as therapeutics for slowing disease progression of amyotrophic lateral sclerosis.

Antibacterial agent 138, a benzothiazole inhibitor, targets bacterial DNA gyrase and topoisomerase IV, exhibiting both favorable solubility and plasma protein binding. It demonstrates antibacterial activity against Gram-positive and Gram-negative strains and functions as a dual GyrB and ParE inhibitor [1].

GUN 00775, also known as N-(m-PEG4)-3,3-Dimethyl-3H-indole-N'-(acid-PEG3)-Benzothiazole Cy5, is a PEG derivative containing a cyanine dye with excitation/emission maximum 649/667 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydophilic PEG spacer increases solubility in aqueous media. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

2-bromomethyl benzothizaole is a derivative of benzothiazole. It is an intermediate and building block electrophilic reagent that has been used in the synthesis of many compounds such as 2-bromo-4-methyl-1,3-benzothiazole, a compound used in the synthesis of novel antifungal agents.

IZTZ-1 is a c-MYC G4 ligand, an imidazole-benzothiazole conjugate. c-MYC G4 is stabilized and c-MYC expression is down-regulated by IZTZ-1. c-MYC G4 is a cell cycle blocker and induces apoptosis, and inhibits the proliferation of B16 cells. Melanoma.

HCVcc-IN-1, a derivative of benzothiazole-2-thiophene S-glycoside, exhibits low toxicity and antiviral properties [1].

Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Riluzole hydrochloride (PK 26124 hydrochloride) is an anticonvulsant compound belonging to the family of sodium channel blockers that inhibits GABA uptake.Riluzole hydrochloride is a sodium-glutamate antagonist with anticancer and neuroprotective activity and can be used to study amyotrophic lateral sclerosis and neurological disorders.