biotin-c5-amino-c5-amino

Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.

Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1.

5-Aminothalidomide is a E3 ligase ligand used in PROTAC technology.

Thalidomide-5-methyl is a Thalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein.

Amino-PEG7-acid, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Amino-PEG14-alcohol (H2N-PEG14-OH) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Amino-PEG12-acid, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Amino-PEG13-amine (H2N-PEG13-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Thalidomide-5-NH2-CH2-COOH (compound 114) is a selective inhibitor of the protomyosin receptor kinase and a ligand for E3 ligase, offering potential for studying various diseases.

Amino-PEG12-Boc, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Amino-PEG12-alcohol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs.

Amino-PEG4-Boc is a PEG-based PROTAC linker suitable for use in PROTAC synthesis[1].

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

Amino-PEG11-amine, a polyethylene glycol (PEG)-based linker with 12 units, facilitates the conjugation of two mono diethylstilbestrol (DES)-based ligands. This strategy enhances the preparation of selective and potent estrogen receptor (ER) antagonists, offering an innovative approach for endocrine therapy in breast cancer treatment.

Amino-PEG10-acid is a PEG-based PROTAC linker utilized in PROTAC synthesis.

Amino-PEG9-alcohol is a PEG-based linker for PROTACs [Proteolysis Targeting Chimeras], facilitating the conjugation of two essential ligands for PROTAC formation and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 5, a combination of an E3 ligase ligand and linker, comprises Thalidomide and its specific Linker. This conjugate acts as a Cereblon ligand to attract the CRBN protein and functions as a crucial intermediate in the production of full PROTAC molecules.

Pomalidomide-5-C5-NH2 hydrochloride is a Pomalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein and can be linked to a protein ligand via a linker to form PROTAC [1].

PROTAC SOS1 degrader-5 (compound 4) serves as an effective degrader of PROTAC SOS1, exhibiting a DC50 of 13 nM. It robustly suppresses the proliferation of NCI-H358 cells, with an IC50 value of 5 nM [1].

Thalidomide-5-propargyne-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, is utilized in recruiting CRBN protein and can be linked to a protein ligand via a linker to form PROTACs [for protein degradation].

PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].

PROTAC BRD9 Degrader-5 is a proteolysis targeting chimera (PROTAC) designed to specifically degrade Bromodomain-containing protein 9 (BRD9).

Thalidomide-5-CH2-NH2 (hydrochloride) is a Thalidomide derivative that acts as a cereblon ligand for CRBN protein recruitment. This compound can be linked to a protein ligand via a linker to form PROTACs.

Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516

Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized chemical compound that functions as an E3 ligase ligand-linker conjugate, combining a Pomalidomide-based cereblon ligand with a linker commonly used in PROTAC technology.

CHO-C-PEG2-C-CHO is a PEG-based linker for PROTACs that connects two essential ligands necessary for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Chloroacetamido-C-PEG3-C3-NHBoc is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs).

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker incorporating biotin for labeling, making it a versatile tool in PROTAC synthesis[1].

m-PEG6-amino-Mal is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Amino-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Amino-PEG6-amine, a polyethylene glycol-based (PEG-based) linker with six units, is utilized for the synthesis of PROTACs.

N-(Amino-PEG3)-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Amino-PEG27-amine, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-SS-PEG12-acid, a cleavable 12-unit polyethylene glycol (PEG) linker, is commonly used in the synthesis of antibody-drug conjugates (ADCs)[1].

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable tetraethylene glycol (4 unit PEG) antibody-drug conjugate (ADC) linker used in the synthesis of ADCs[1].

K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1].

Amino-PEG10-Boc is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Amino-PEG14-acid is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-PEG23-amine is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands, which is crucial for creating PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Amino-PEG4-C2-amine, a PEG-based linker (4 units) for PROTAC development, facilitates the synthesis of PROTACs.

DBCO-C-PEG1 is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, facilitating selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Amino-PEG5-Boc is a PEG-based linker for PROTACs, crucial for joining two essential ligands and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker used in PROTAC synthesis [1].

Amino-PEG5-CH2COOH is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells (PROTACs) [ubiquitin-proteasome system].