bis(mpeg8amido)hexanoic acid

Bis-(m-PEG8-amido)-hexanoic acid is a polyethylene glycol (PEG)-based linker used in synthesizing proteolysis targeting chimeras (PROTACs) [1].

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

Bis-CH2-PEG2-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Mal-amido-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a polyethylene glycol (PEG)-based linker used for PROTAC synthesis [1].

N-(Biotin-PEG4)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker molecule used in the synthesis of PROTACs[1].

Mal-amido-PEG12-acid is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by connecting two essential ligands and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Ald-Ph-amido-PEG4-C2-acid is a noncleavable linker used in the development of antibody-drug conjugates (ADC).

Bis-PEG10-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Bis-Mal-Lysine-PEG4-acid is a PEG-based PROTAC linker used for PROTAC synthesis [1].

Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11-unit polyethylene glycol (PEG) linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Bis-PEG13-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker extensively used in the synthesis of PROTACs (proteolysis targeting chimeras)[1].

Ald-Ph-amido-PEG2-C2-acid is a PEG-based PROTAC linker used for synthesizing PROTACs[1].

Bis-PEG4-sulfonic acid is a PEG-based linker for PROTACs, facilitating the conjugation of essential ligands critical for PROTAC molecule formation. It enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PEG4-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative functioning as a linker in PROTAC synthesis, specifically designed for creating proteolysis-targeting chimeras (PROTACs)[1].

Biotin-bis-amido-SS-NHS is an alkyl ether-based PROTAC linker used in the synthesis of PROTACs.

Bis-(m-PEG4)-amidohexanoic acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-Me-N-bis(PEG4-acid) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Mal-amido-PEG3-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, [Biomedical applications]. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Boc-N-bis(PEG2-acid) is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis [1].

Mal-amido-PEG24-acid is a PEG-based linker for PROTACs that joins two essential ligands, critical for the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG21-acid is a PEG-based linker for PROTACs that connects two crucial ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

N-Benzyl-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the synthesis of PROTACs[1].

Mal-amido-PEG10-acid is a PEG-based linker used in PROTACs, facilitating the combination of two key ligands essential for PROTAC molecule formation. This linker aids in selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Sulfone-Bis-PEG4-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used for synthesizing PROTACs, consisting of an amino group and two terminal carboxylic acids[1].

Bis-PEG9-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

NH-bis(PEG2-C2-acid) is a PEG-based linker essential for PROTACs, facilitating the conjugation of two critical ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Bis-PEG11-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a polyethylene glycol (PEG)-based linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Bis-(PEG6-acid)-SS, a cleavable linker composed of a six-unit PEG (polyethylene glycol) moiety, is specifically employed in the synthesis of antibody-drug conjugates (ADCs)[1].

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in the synthesis of PROTACs[1].

(S,R,S)-AHPC-amido-C5-acid is a chemical compound containing a VHL ligand for E3 ubiquitin ligase and a PROTAC linker, utilized in designing XY028-133[1].

Mal-amido-PEG9-acid is a PEG-based linker for PROTACs, crucial for joining two essential ligands and facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-amido-PEG16-acid is a PEG-based linker used in PROTAC molecules, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

N,N'-bis-(Acid-PEG3)-benzothiazole Cy5 is a polyethylene glycol (PEG)-derived PROTAC linker used in PROTAC synthesis [1].

Boc-N-amido-PEG3-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG17-acid, a PEG-based linker for PROTACs, joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG5-acid (PROTAC Linker 36) is a polyethylene glycol (PEG) linker used in the synthesis of CP5V, a PROTAC that selectively degrades Cdc20[1].

N-Mal-N-bis(PEG2-acid) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system in cells.

Bis-PEG8-acid, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs)[1]. It serves as a cleavable ADC linker, facilitating the development of specialized compounds.

Mal-amido-PEG8-C2-acid (US2018339985, example 142) is a noncleavable linker for antibody-drug conjugates (ADCs) [1].

PEG3-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

N-(PEG3-acid)-N-bis(PEG3-amine) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].