bispeg15acid

Bis-PEG15-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

15-Hydroxy Pentadecanoic Acid Methyl Ester is a hydroxylated fatty acid methyl ester (FAME) crucial for synthesizing musk-odored macrocyclic lactones, specifically cyclopentadecanolide and exaltolide [Matreya, LLC. Catalog No. 1882].

12(Z),15(Z)-Heneicosadienoic acid, an ω-6 very long-chain polyunsaturated fatty acid, serves as a positional isomer of heneicosadienoic acid, which is scarcely found in living organisms.

ent-9-Hydroxy-15-oxokauran-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5577 and the CAS number is 77658-45-8.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3956 and the CAS number is 77658-39-0.

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

Kaur-16-en-18-oic acid, 15-oxo- (7CI,8CI) is a useful organic compound for research related to life sciences. The catalog number is T124445 and the CAS number is 6620-00-4.

16-Acetoxy-6-oxo-7,13-labdadien-15-oic acid is a useful organic compound for research related to life sciences and the catalog number is T130200.

Extracted from Pharbitis nil (Linn.)Choisy fruit.

15-Deoxypulic acid is a natural product of Pulicaria, Asteraceae. The catalog number is TN6525 and the CAS number is 95523-05-0. 15-Deoxypulic acid can be used as a reference standard.

15,16-Dihydro-15-methoxy-16-oxohardwickiic acid is a natural product for research related to life sciences. The catalog number is TN2629 and the CAS number is 115783-35-2.

7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity.

15-Methoxy-16-oxo-15,16H-strictic acid is a natural product of Pulicaria, Asteraceae. The catalog number is TN6526 and the CAS number is 1356388-38-9. 15-Methoxy-16-oxo-15,16H-strictic acid can be used as a reference standard.

9-Hydroxy-13E-labden-15-oic acid is a useful organic compound for research related to life sciences and the catalog number is T126043.

3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic acid, a microalgal polyunsaturated fatty acid (PUFA), is identified in G. kowalevskii and serves as a chemotaxonomic biomarker for microalgae and dinoflagellates.

Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dep

16-Acetoxy-17-hydroxy-7,13Z-labdadien-15-oic acid is a useful organic compound for research related to life sciences and the catalog number is T130199.

15-Hydroxy-16-kauren-19-oic acid is a useful organic compound for research related to life sciences and the catalog number is T131456.

ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation of the endothelial NO-cGMP pathway, the opening of K+ channels and the alteration on Ca2+ mobilization.

3-Clerodene-2,15-diol, 15-Carboxylic acid, 2-keton is a useful organic compound for research related to life sciences and the catalog number is T130187.

(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.

9-Oxo-2,7-bisaboladien-15-oic acid is a natural product for research related to life sciences. The catalog number is TN3328 and the CAS number is 93888-59-6.

15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals and is a common minor impurity in commercial preparations of the bulk drug compound. Although much less potent than latanoprost, 15-keto Latanoprost can still produce a small but measurable decrease (1 mm Hg) in intraocular pressure in normal cynomolgus monkeys at a dose of 1 μg eye. It also acts as a miotic in normal cats, causing an 8 mm Hg reduction in pupillary diameter at 5 μg eye, though it is not as potent as many other F-type prostaglandins, such as prostaglandin F2α, which achieves the same effect at less than 1 μg eye.

16-Nor-15-oxodehydroabietic acid is a natural product from Pinus massoniana.

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.

15-methyl Palmitic Acid is a methylated fatty acid that is widely found in animal lipids and may be involved in the regulation of fat metabolism.

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid. It has been used to study the desaturation and elongation of ω-3 polyunsaturated fatty acids. It is elongated to form C26:5 or acted on by δ6 desaturase to form C24:6. 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is found at low levels in mouse brain and spleen and levels decrease in the brain and spleen of old and exceptionally old mice.

16,18-Dihydroxy-3,13-clerodadien-15-oic acid is a useful organic compound for research related to life sciences and the catalog number is T130513.

ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3955 and the CAS number is 81263-96-9.

16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity.

ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid is a natural product for research related to life sciences. The catalog number is TN3953 and the CAS number is 81264-00-8.

ent-17-Hydroxykaur-15-en-19-oic acid, a natural compound present in the leaves of the aromatic tree, exhibits an IC50 of 17.63 μg mL against human prostate cells.

Compound 9, 15-Nor-14-oxolabda-8(17),12E-diene-18-oic acid, is an isolated compound derived from the roots of Chloranthus spicatus [1].

15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.

(15:3)-Anacardic acid is a useful organic compound for research related to life sciences. The catalog number is T126498 and the CAS number is 103904-73-0.

ent-17-Hydroxykaura-9(11),15-dien-19-oic acid is a natural product from Wedelia trilobata.

N-Boc-15-aminopentadecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

15-Nor-14-oxolabda-8(17),12-dien-18-oic acid is a useful organic compound for research related to life sciences and the catalog number is T126495.

(-)-Cadin-4,10(15)-dien-11-oic acid is a natural product of Acorus, Araceae. The catalog number is TN6478 and the CAS number is 1124353-23-6. (-)-Cadin-4,10(15)-dien-11-oic acid can be used as a reference standard.

ent-3beta,18-Dihydroxylabda-8(17),13E-dien-15-oic acid is a natural product for research related to life sciences. The catalog number is TN3947 and the CAS number is 99624-39-2.

3α-Cinnamoyloxy-9β,17-dihydroxy-ent-kaur-15-en-19-oic acid is a natural product for research related to life sciences. The catalog number is TN5613 and the CAS number is 2186648-60-0.

15-Hydroxy-7-oxodehydroabietic acid is a natural product of Pinus, Pinaceae. The catalog number is TN2638 and the CAS number is 95416-25-4. 15-Hydroxy-7-oxodehydroabietic acid can be used as a reference standard.

15-Azido-pentadecanoic acid, also known as Azido Palmitic Acid, serves as a click chemistry reagent due to its azide group. This compound is instrumental in the identification and characterization of post-translationally palmitylated proteins through a straightforward two-step labeling and detection methodology [1]. It can partake in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules and also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules featuring DBCO or BCN groups, showcasing its versatility in biochemical applications.

ent-6,11-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN3951 and the CAS number is 81263-97-0.