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By Target- PDGFR
- c-Kit(1)
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Results for "
blu285
" in TargetMol Product Catalog- Inhibitors & Agonists1
Avapritinib
BLU-285
T51091703793-34-3
Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.
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