bno peg1 ch2cooh

BnO-PEG1-CH2COOH is a PEG-based linker for PROTACs that connects two essential ligands, critical for forming PROTAC molecules, and facilitates selective protein degradation using the ubiquitin-proteasome system within cells.

Cbz-NH-PEG1-CH2COOH, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Amine-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

m-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].

Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH, a chemical compound that serves as a linker incorporating TLR4 inhibitor TLR4-IN-C34, effectively inhibits TLR4 in both enterocytes and macrophages, significantly reducing systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis [1].

Amine-PEG-CH2COOH (MW 3400) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs).

Thiol-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG) derivative frequently used in the construction of PROTACs, bifunctional compounds designed for targeted protein degradation [1].

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized E3 ligase ligand-linker conjugate, incorporating the cereblon ligand from Pomalidomide and a linker used in PROTAC technology. It facilitates targeted protein degradation by modulating E3 ligase activity, thereby enabling the selective elimination of specific proteins of interest.

Fmoc-NH-PEG1-CH2COOH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based linker suitable for the synthesis of PROTACs, which are compound complexes designed to selectively degrade target proteins[1].

Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a chemical linker with the TLR4 inhibitor TLR4-IN-C34, which inhibits TLR4 in enterocytes and macrophages, reducing systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis [1].

Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC linker used for the EED-targeted PROTAC [1].

BnO-PEG1-CH2CO2tBu is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Tos-PEG1-O-CH2COOH (PROTAC Linker 28) is a PEG-based linker used in the synthesis of PROTACs [1].

Fmoc-N-amido-PEG-CH2COOH (MW 5000), a PEG-based PROTAC linker, is used in PROTAC synthesis [1].

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate, an ADC linker, is a glutathione-cleavable compound used for attaching monoclonal antibodies (mAb) in antibody-drug conjugates (ADCs), specifically referring to the Alkyl-Chain composition of the linker portion of these molecules [1].

DSPE-PEG-CH2COOH (MW 2000) is a polyethylene glycol (PEG)-based linker molecule specifically designed for synthesizing protein-targeting chimeras (PROTACs)[1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

Bromo-PEG1-CH2COOH is a PROTAC linker utilized in the synthesis of PROTACs [1].

m-PEG-CH2COOH (MW 20000) functions as a PEG-based PROTAC linker used in the synthesis of PROTACs[1].

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in the synthesis of PROTACs[1].

m-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG) derived PROTAC linker used in the synthesis of PROTACs. [1]

HO-PEG-CH2COOH (MW 5000), a polyethylene glycol (PEG)-based PROTAC linker, serves as a valuable component in the synthesis of PROTACs[1].

Thiol-PEG-CH2COOH (MW 3400) is a Polyethylene Glycol (PEG) derivative used as a PROTAC linker for PROTAC synthesis[1].

PROTAC VEGFR-2 Degrader-1 (PROTAC-1), a specific degrader of PROTAC VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and exhibits low anti-proliferative effects on EA.hy926 cells (IC50 > 100 μM) [1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation (ADC).

Boc-NH-PEG1-CH2COOH is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

HO-PEG-CH2COOH (MW 3400) is a PEGylated PROTAC linker with a molecular weight of 3400, serving as a PEG-based building block for PROTAC synthesis[1].

DSPE-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker. It serves as an essential component in the synthesis of PROTACs, enabling the targeted degradation of specific proteins[1].

Fmoc-N-amido-PEG-CH2COOH (MW 3400) is a PEG-based PROTAC linker used in PROTAC synthesis[1].

Hydroxy-PEG1-(CH2)2-Boc is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1].

Mal-amido-(CH2COOH)2, also known as compound 7a, is an intermediate compound that contains maleimidoethyl for use in hydrophilic ADC linker synthesis[1].

Amine-PEG-CH2COOH (MW 2000) is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Thiol-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker used for the synthesis of PROTACs[1].