boc-pip-alkyne-ph-cooh

Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].

Boc-C16-COOH is a alkyl-chain-based PROTAC linker. Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Boc-C14-COOH is a alkyl-chain-based PROTAC linker. Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

(VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH), also known as (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH, is a conjugate compound comprising a ligand-linker that targets E3 ligase and features a VHL ligand on one end. It is employed in PROTAC technology applications.

Ph-Bis(C1-N-(C2-NH-Boc)2) is a versatile alkyl chain-derived linker used in the synthesis of PROTACs [1].

Ald-Ph-PEG2-NH-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Alkyne-ethyl-PEG1-Boc is a PEG-based linker for PROTACs that connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG4-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the [ubiquitin-proteasome] system within cells.

Ald-Ph-PEG5-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enables selective protein degradation through the ubiquitin-proteasome system within cells.

Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.

Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker used for PROTAC synthesis [1].

Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG4-based linker used in PROTACs synthesis [1].

Ald-Ph-PEG2-Boc is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Ald-Ph-amido-PEG3-C-COOH is a noncleavable linker used in the development of antibody-drug conjugates (ADCs).

Ald-Ph-amido-PEG2-C2-Boc is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC linker used for the EED-targeted PROTAC [1].

Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEGylated PROTAC linker suitable for PROTAC synthesis [1].

(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is an E3 ligase ligand-linker conjugate designed for targeting the EED protein in PROTAC applications[1].

Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker used for synthesizing PROTAC ARD-266[1].

Ald-Ph-amido-PEG3-C1-Boc is a polyethylene glycol (PEG) linker used specifically in antibody-drug conjugates (ADC).

Ald-Ph-PEG6-Boc is a PEG-based linker for PROTACs that joins two essential ligands, crucial for the formation of PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG4-NH-Boc, a PEG-based linker for PROTACs, connects two essential ligands, crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thalidomide-azetidine-C-PIP-C-boc is a conjugate of E3 ligase ligand and linker, comprising Thalidomide and the corresponding linker. As a Cereblon ligand, Thalidomide-azetidine-C-PIP-C-boc recruits CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.

Thalidomide-PIP-(R)C-pyrrolidine-boc is a conjugate comprising an E3 ligase ligand and a linker, specifically containing Thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of the CRBN protein, and is a crucial intermediate in synthesizing complete PROTAC molecules.