boc-val-ala-pab-pnp

Boc-Val-Ala-PAB-PNP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates the attachment of drugs to antibodies, allowing for targeted delivery and release of therapeutic agents within the body, making it an important component in ADC development.

Val-cit-PAB-OH is an ADC linker that is cleavable.

Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).

DBCO-Val-Cit-PABC-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis[1].

Mal-PEG8-Val-Cit-PAB-MMAE is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

SuO-Val-Cit-PAB-MMAE is an ADC (antibody-drug conjugate) linker comprising the anti-mitotic monomethyl auristatin E (MMAE, a tubulin inhibitor) connected through the SuO-Val-Cit-PAB peptide.

Fmoc-Val-Cit-PAB-MMAE is consisted of the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). Fmoc-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC.

Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2-unit polyethylene glycol (PEG) based ADC linker utilized in the construction of antibody-drug conjugates (ADCs)[1].

Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker[1].

Boc-Val-Cit-OH is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker employed for synthesizing antibody-drug conjugates (ADCs)[1]. It also serves as a PEG-based PROTAC linker for the synthesis of PROTACs[2].

Mal-PEG2-Val-Cit-amido-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

MC-Val-Ala-PAB-PNP is a cleavable ADC linker. MC-Val-Ala-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-Phe-Lys(Trt)-PAB-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis, specifically designed for use in ADC synthesis.

MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.

MAL-di-EG-Val-Cit-PAB-MMAE comprises the linker MAL-di-EG-Val-Cit-PAB and the potent tubulin inhibitor MMAE, which are essential components of antibody-drug conjugates (ADCs).

Boc-Val-Cit-PAB is a cleavable ADC linker. Boc-Val-Cit-PAB used in the synthesis of antibody-drug conjugates (ADCs).

MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavable linker, MC-Val-Cit-PAB.

Ala-Ala-Asn-PAB is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs)[1].

MAL-di-EG-Val-Cit-PAB-MMAF refers to a chemical compound that comprises the linker (MAL-di-EG-Val-Cit-PAB) and the potent blocker of tubulin polymerization (MMAF, Monomethyl auristatin F)[1].

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable tetraethylene glycol (4 unit PEG) antibody-drug conjugate (ADC) linker employed in the synthesis of ADCs[1].

Mal-amido-PEG8-val-gly-PAB-OH is an eight-unit PEG cleavable linker frequently employed in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-(PEG2-Val-Cit-PAB)2 is a dual cleavable ADC linker for antibody-drug conjugates (ADCs).

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.

Mal-Phe-C4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker featuring a Maleimide functional group. It is employed in the synthesis of ADCs.

OPSS-Val-Cit-PAB-OH is an ADC linker utilized for the synthesis of antibody-drug conjugates (ADCs) [1].

MC-Val-Cit-PAB-dimethylDNA31 is a drug-linker conjugate employed in antibody-drug conjugates (ADCs) that exhibits robust antitumor efficacy. This conjugate utilizes the ADC linker, MC-Val-Cit-PAB, to link to the potent antitumor agent dimethylDNA31. Notably, dimethylDNA31 also demonstrates significant bactericidal activity against both persister and stationary-phase Staphylococcus aureus.

Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB is a cleavable three-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

mDPR-Val-Cit-PAB-MMAE consists the ADCs linker (mDPR-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), mDPR-Val-Cit-PAB-MMAE is an antibody drug conjugate.

MC-Val-Cit-PAB-Retapamulin is a drug-linker conjugate for antibody-drug conjugates (ADC) that exhibits potent antitumor activity. This compound utilizes Retapamulin, a ribosome inhibitor, connected through the ADC linker MC-Val-Cit-PAB.

MC-Val-Cit-PAB-vinblastine is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), featuring vinblastine (a microtubule protein inhibitor) connected through the MC-Val-Cit-PAB ADC linker.

Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-drug-conjugation (ADC).

Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.

Azido-PEG5-Ala-Ala-Asn-PAB is a cleavable 5-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Fmoc-PEG4-Ala-Ala-Asn-PAB is a four-unit polyethylene glycol (PEG) linker, cleavable in nature. It is specifically employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-PEG4-Val-Cit-PAB, a cleavable ADC linker incorporating a Maleimide moiety, finds application in the construction of antibody-drug conjugates (ADCs)[1].

Mal-amido-PEG2-Val-Cit-PAB-OH is a bi-functional polyethylene glycol (PEG) linker, comprised of two PEG units, that can be cleaved. It is specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].

Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs), which are innovative therapeutic agents that combine the targeting ability of antibodies with potent cytotoxic drugs.

Azido-PEG3-Val-Cit-PAB-OH is a cleavable three-unit polyethylene glycol antibody-drug conjugate (ADC) linker utilized in ADC synthesis [1].

MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug.

Azido-PEG4-Val-Cit-PAB-OH is a 4-unit PEG ADC linker and a PEG-based PROTAC linker. It is employed for the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2].

Cbz-Phe-(Alloc)Lys-PAB-PNP serves as a cleavable linker in the design of antibody-drug conjugates (ADC).

Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker employed in the synthesis of ADCs.

MC-Val-Cit-PAB-Auristatin E is an antibody-drug conjugate (ADC) linker compound featuring Auristatin E, a potent cytotoxic tubulin modifier, connected through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

MC-Val-Cit-PAB-clindamycin is an antibody-drug conjugate (ADC) linker that combines the potent antitumor properties of clindamycin, a protein synthesis inhibitor, with the ADC linker MC-Val-Cit-PAB, to enhance its ability to target and kill cancer cells effectively.

SC-Val-Cit-PAB is a cleavable ADC linker for antibody-drug conjugates (ADCs).

mDPR(Boc)-Val-Cit-PAB is a cleavable linker employed in antibody-drug conjugates (ADCs) [1]. This chemical compound serves as a reliable linker in the formation of ADCs, which are biopharmaceuticals that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs for targeted cancer therapy [1].

MC-Val-Cit-PAB-carfilzomib is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), comprising the irreversible proteasome inhibitor carfilzomib, connected through the ADC linker MC-Val-Cit-PAB.