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brca1 tbrct

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    2
    TargetMol | Activity
BRCA1-IN-1
T106001622262-74-1
BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 with an IC50 of 0.53 μM and a Ki of 0.71 μM.
  • $2,420
10-14 weeks
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Bractoppin
T88732290527-07-8
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
  • $45
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