bromoacetamido-peg-8-acid

Bromoacetamido-PEG8-acid, a PEG-derived PROTAC linker, is suitable for synthesizing PROTACs[1].

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Bromoacetamido-PEG2-C2-acid is a polyethylene glycol (PEG)-based linker utilized in PROTAC synthesis[1].

Bromoacetamido-PEG3-C2-acid is a polyethylene glycol (PEG) derived linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker used for PROTAC synthesis[1] and serves as a cleavable 4-unit PEG ADC linker in the creation of antibody-drug conjugates (ADCs)[2].