bromoacetamido-peg-9-ethylcarbamoyl-c4-boc

Bromoacetamido-PEG9-ethylcarbamoyl-C4-Boc is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker used in the synthesis of PROTACs[1].

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].

Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.

Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker used in PROTAC synthesis [1].

Azido-PEG3-C-Boc is a PEG-based linker for PROTACs that connects two essential ligands, crucial for the formation of PROTAC molecules, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Bromoacetamido-PEG9-ethylcarbamoyl-C8-Boc represents a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].

N-Boc-cis-4-hydroxy-D-proline methyl ester (catalog number: T66907, CAS number: 114676-69-6) is a valuable organic compound used in life sciences research.

4-Boc-amino-22-dimethylbutyric acid is an alkyl ether-derived PROTAC linker, suitable for PROTAC synthesis.

Azido-PEG8-C-Boc is a PEG-based linker for PROTACs that connects two essential ligands, crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl ether-based linker suitable for PROTAC synthesis [1].

C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile alkyl ether-based PROTAC linker used for synthesizing PROTACs [1].

9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

N-Boc-cis-4-hydroxy-L-proline is a valuable organic compound used in life sciences research (catalog number: T66248, CAS number: 87691-27-8).

Boc-NH-PEG-amine (MW 3400) is a PEG-based PROTAC linker used in PROTAC synthesis[1].

Boc-NH-PEG-amine (MW 5000) is a PEG-based PROTAC linker used for the synthesis of PROTACs [1].

Thalidomide-azetidine-C-PIP-C-boc is a conjugate of E3 ligase ligand and linker, comprising Thalidomide and the corresponding linker. As a Cereblon ligand, Thalidomide-azetidine-C-PIP-C-boc recruits CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.

Thalidomide-PIP-(R)C-pyrrolidine-boc is a conjugate comprising an E3 ligase ligand and a linker, specifically containing Thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of the CRBN protein, and is a crucial intermediate in synthesizing complete PROTAC molecules.

N-Boc-PEG-t-butyl ester is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

N-Boc-cis-4-Hydroxy-D-proline [Catalog Number: T65722, CAS Number: 135042-12-5] is a valuable organic compound for life sciences research.

Bromoacetamido-PEG9-ethylcarbamoyl-C12-Boc is a polyethylene glycol (PEG) derived linker used in synthesizing proteolysis-targeting chimeras (PROTACs) [1].

C-NH-Boc-C-Bis-(C1-PEG1-PFP), a polyethylene glycol (PEG)-derived PROTAC linker, is utilized in the synthesis of PROTACs [1].

Bromoacetamido-PEG8-Boc is a PEG-based linker compound used in the synthesis of PROTACs, molecules designed for targeted protein degradation [1].

Bromoacetamido-C2-PEG2-NH-Boc is a polyethylene glycol (PEG)-based linker with a bromoacetamido functional group and a tert-butoxycarbonyl (Boc) protecting group, used in the synthesis of proteolysis-targeting chimeras (PROTACs), which are innovative compounds for targeted protein degradation[1].

Boc-NH-PEG-amine (MW 2000) is a polyethylene glycol (PEG) linker utilized in PROTAC synthesis[1].

Bromoacetamido-PEG4-C2-Boc is a polyethylene glycol (PEG)- and alkyl ether-based linker commonly used for synthesizing proteolysis targeting chimeras (PROTACs)[1].

Bromoacetamido-PEG3-NH-Boc is a polyethylene glycol (PEG)-based linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Bromoacetamido-PEG3-C2-Boc is a polyethylene glycol (PEG) derived linker suitable for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].