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Trimethoprim sulfate is a pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

Trimethoprim hydrochloride, a bacteriostatic antibiotic and dihydrofolate reductase inhibitor, demonstrates efficacy against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria. It has research applications for urinary tract infections, Shigellosis, and Pneumocystis pneumonia. Additionally, when combined with zinc, it can inhibit the infection of Influenza A virus in chick embryos [1] [2] [3] [4].

Trimethoprim lactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria . Trimethoprim lactic has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment.

Trimethoprim 3-oxide trimethoprim primary metabolite.

Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.