c-di-imp

Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies.

C-di-IMP disodium, a STING agonist, is utilized in tumor research [1].

4'-O-Methyllucenin II (Diosmetin 6,8-di-C-glucoside) is a useful organic compound for research related to life sciences and the catalog number is T123819.

Cyclic diadenylate (c-di-AMP) sodium functions as a STING agonist by binding to the STING transmembrane protein, thus activating the TBK3-IRF3 signaling pathway. This activation prompts the production of type I IFN and TNF. Additionally, c-di-AMP sodium serves as a bacterial second messenger in Gram-positive bacteria, where it plays crucial roles in regulating cell growth, survival, and virulence, as well as the host immune response. It also acts as a potent mucosal adjuvant by stimulating both humoral and cellular responses [1] [2] [3] [4].

Apigenin 6,8-di-C-alpha-L-arabinopyranoside is a useful organic compound for research related to life sciences. The catalog number is T124311 and the CAS number is 73140-47-3.

6,8-Di-C-β-D-xylopyranoside (compound 3bb) is a xylopyranoside that has been isolated from the orchid Dendrobium huoshanensis [1].

Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) plus c-di-IMP through the intranasal route show a humoral immune response, evidenced by an increase in IgG titers up to 2-fold compared to mice immunized with β-gal alone. Mice immunized with β-gal plus c-di-IMP also exhibit a Th1/Th2 response, indicating that the adjuvant activity of c-di-IMP leads to a cellular immune response as well.

1,2-Di-O-acetyl-3,5-di-O-benzoyl-3-beta-C-methyl-D-ribofuranose is a Carbohydrate Derivative.

Nucleoside Derivatives - Fluoro-modified nucleosides; 4’-Modified nucleosides

Phloretin 3',5'-Di-C-glucoside is a useful organic compound for research related to life sciences and the catalog number is T124963.

Nucleoside Derivatives - 2’-Modified nucleosides, 7-Deaza-purine nucleosides, Halo-nucleosides

1',2'-Di-O-acetayl-3',5'-di-O-benzoyl-3'-beta-C-ethynyl-D-ribofuranose is a carbohydrate derivative.

c-di-AMP (Cyclic diadenylate) is a STING agonist. It binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway.

9-(2,5-Di-O-benzoyl-2-C-beta-ethynyl-beta-D-ribofuranosyl)-6-chloropurine is a useful organic compound for research related to life sciences and the catalog number is TNU1616.

4-C-(Iodomethyl)-1,2-di-O-(1-methylethylidene)-3,5-bis-O-(phenylmethyl)-a-D-ribofuranose is a Carbohydrate Derivative.