c-kit-in-3 maleate

c-Kit-IN-3 maleate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism.

c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).

c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.

7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine is a building block.1It has been used in the synthesis of PI3K inhibitors. 1.Scott, W.J., Hentemann, M.F., Rowley, R.B., et al.Discovery and SAR of novel 2,3-dihydroimidazo[1,2-c]quinazoline PI3K inhibitors: Identification of copanlisib (BAY 80-6946)ChemMedChem.11(14)1517-1530(2016)

3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1).

ligand for the D2 receptor

4-Chloro-2-(2,6-dioxopiperidin-3-yl)-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione is a useful organic compound for research related to life sciences and the catalog number is T64660.

3'-beta-C-Ethynyluridine is a Nucleoside Derivative - 3'-Modified nucleoside.

5'-O-Benzoyl-3'-O-(4-methoxybenzoyl)-2'-O,4'-C-methyleneuridine is a Nucleoside Derivative - LNA-related nucleoside.

3'-beta-C-Ethynyl-N6-isopentenyl adenosine is a Nucleoside Derivative - 3'-Modified nucleoside, 6-Modified purine nucleoside.

c-Kit-IN-3 D-tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).

Nucleoside Derivatives - 4-Deoxy pyrimidine nucleosides; 3’-Modified nucleosides

3'-beta-C-Methyl-inosine is a Nucleoside Derivative - 3'-Modified nucleoside.

3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol is a useful organic compound for research related to life sciences. The catalog number is TNU1641 and the CAS number is 1117893-19-2.

Nucleoside Derivatives - Thio-nucleosides; 3’-Modified nucleosides

Rev 2’-O-MOE-C(Bz)-5’-amidite; N4-Benzoyl-3'-O-(4,4’-dimethoxy trityl)-2'-O-(2-methoxyethyl)cytidine-5’-CED phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is TNU1531.

3'-O-Me-C(Bz)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

Iriflophenone 3-C-glucoside (Iriflophenone 3-C-β-D-glucopyranoside),has antioxidant activity,isolated from Cyclopia genistoides.

3-Oxo-4-benzyl-3,4-dihydro-1H-pyrrolo [2,1-c] oxazine-6-methylal is a natural product for research related to life sciences. The catalog number is TN6641 and the CAS number is 60026-28-0.

DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a Nucleoside Phosphoramidite.

4'-alpha-C-Allyl-2',3'-bis(O-t-butyldimethylsilyl)uridine is a Nucleoside Derivative - 4'-Modified nucleoside; Protected nucleoside w/NH2/OH open.

c-ABL-IN-3, a highly effective c-Abl inhibitor, exhibits promising potential for studying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), as well as cancer [1]. The activation of c-Abl has been strongly implicated in a range of diseases, notably cancer [1]. It offers valuable opportunities for research in these fields [1].

2',3',5'-Tri-O-benzoyl-2'-C-methyl-5-methyluridine is a 2'-C-Methyl nucleoside; 5-Modified pyrimidine nucleoside.

Nucleoside Derivatives - 4’-Modified nucleosides; 3-Deazauridines

3'-Deoxy-3'-alpha-C-methylcytidine is a Nucleoside; Used for nucleoside and nucleic acid modifications.

3'-Deoxy-3'-a-C-methyladenosine is a Nucleoside Derivative - 3'-Modified nucleoside.

2'-Fluoro-2'-deoxy-ara-C(Bz)-3'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - Fluoro-modified nucleoside.

3'-beta-C-Methyl-N6-(p-methoxybenzyl)adenosine is a Nucleoside Derivative - 3'-Modified nucleoside, 6-Modified purine nucleoside.

Antiproliferative Against-3 (comp 33) demonstrates significant activity against Hela (IC 50 = 0.21 µM), A549 (IC 50 = 0.39 µM), and MCF-7 (IC 50 = 0.33 µM) cell lines. Additionally, it induces apoptosis in a dose-dependent manner by arresting A549 cells in the G1 phase.

5’-O-Benzoyl-3’-O-(4-methoxybenzyl)-2’-O,4’-C-methyleneuridine is a purine nucleoside analog with broad antitumor activity, primarily targeting indolent lymphoid malignancies. Its anticancer mechanisms include inhibiting DNA synthesis and inducing apoptosis, among others [1].

3’-Beta-C-Methyl-N6-isopentenyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine , Clofarabine , Fludarabine phosphate and Vidarabine [1] .

5-Chloro-3-phenylbenzo[c]isoxazole is a useful organic compound for research related to life sciences. The catalog number is T66589 and the CAS number is 719-64-2.

3'-beta-C-Methyluridine is a Nucleoside Derivative - 3'-Modified nucleoside.

2',3',5'-Tri-O-benzoyl-2'-C-methyl-5-methoxyuridine is a 2'-C-Methyl nucleoside; 5-Modified pyrimidine nucleoside.

3'-beta-C-Methyl-5-methyluridine is a Nucleoside Derivative - 3'-Modified nucleoside.

c-Kit-IN-3 tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).

Nucleoside Derivatives - 5’-Modified nucleosides; 3-Deazauridines

N6-(3-Methoxybenzyl)-2'-C-methyl adenosine is a Nucleoside Derivative - 6-Modified purine nucleoside; 2'-Modified nucleoside.

Nucleoside Derivative –4’-Modified nucleosides; Protected nucleosides with NH2/OH group

5-Fluoro-3'-beta-C-methyluridine is a Nucleoside Derivative - 3'-Modified nucleoside, 5-Modified pyrimidine nucleoside, Fluoro-modified nucleoside.

3'-beta-C-Ethynyladenosine is a Nucleoside Derivative - 3'-Modified nucleoside.

3'-Deoxy-3'-a-C-methyl-5-fluorouridine is a Nucleoside Derivative - 3'-Modified nucleoside, 5-Modified pyrimidine nucleoside, Fluoro-modified nucleoside.

Nucleoside Derivatives - 2’-Modified nucleosides; Scaffolds and Templates;Bi-Tricyclic nucleosides

2',3',5'-Tri-O-benzoyl-2'-C-methyl-5-fluorouriddine is a Fluoro-modified nucleoside; 2'-C-methyl nucleoside; 5-Modified pyrimidine nucleoside.

c-Kit-IN-3 hydrochloride is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).

Nucleoside Derivatives - 3’-Modified purine nucleosides

c-Met/HDAC-IN-3, a dual inhibitor targeting both c-Met and HDAC, exhibits potent inhibitory activity with IC50 values of 12.50 nM for c-Met and 26.97 nM for HDAC1. It induces apoptosis and causes cell cycle arrest in the G2/M phase.

3'-beta-C-Methyl-5-methylcytidine is a Nucleoside Derivative - 3'-Modified nucleoside.