c18 dthreo ceramide (d18:1/18:0)

C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidaseBiochemistry40(32)9657-9668(2001)

c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).

Questiomycin A derivatives 18 TFA is A Questiomycin A derivative with antibacterial and anticancer activity and inhibition of the expression of the cell-protective ER chaperone protein GRP78.

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside), isolated from the Caribbean sponge [Tectitethya crypta], is a methoxyadenosine derivative with anti-inflammatory activity, analgesic, and vasodilation properties.

1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a fluoro-modified nucleoside, specifically an Arabino-nucleoside.

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism.

1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride (1-PPZ-DHC) is a compound used as a molecular structural unit. It is an analog of the natural product piperazine and has a wide range of biological activities, including anti-inflammatory, anti-tumor and antibacterial activities. It has also been studied for the treatment of neurological disorders such as Alzheimer's and Parkinson's.

Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel- is an estrogen receptor beta (ERβ) agonist.

Kaempferol-3-O-β-D-glucosyl(1-2)rhamnoside is a natural peoduct isolated from Arabian jasmine

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv showed high local anti-inflammatory potency and high lung selectivity when tested on Sprague Dawley rats.

(2S)-1-O-p-coumaroyl-2-O-acetyl-3-O-β-D-glucopyranosylglycerol is a useful research compound for many research applications, including the fields of chemistry and life sciences, among others.

D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.

1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.

DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of anticancer DNA damage compounds.

C-Type Natriuretic Peptide (CNP) (1-22), human acetate is an agonist of natriuretic peptide receptor B (NPR-B), an endothelial-derived relaxant and growth inhibitory factor. C-Type Natriuretic Peptide (CNP) (1-22), human acetate inhibits cAMP synthesis stimulated by histamine and 5-HT or directly by Forskolin.

IRBP acetate(211426-18-5 free base) (Interphotoreceptor Retinoid Binding Protein Fragment IRBP) is a 20-residue peptide, which is a major pathogenic epitope. It exists in the first homologous repeat of interstitial visual pigment Binding Protein peptide (IRBP 161-180) and can induce post-uveitis (EAU).

(25R)-3β,17α-dihydroxy-5α- spirostan-6-one3-O-α-L- rhamnopyranosyl-(1→2)-β- D-glucopyranoside is a natural product isolated from the bulbs of Lilium brownii var. viridulum.

Tripeptide-1 Acetate is a biologically active peptide

3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one is a compound that has been extensively investigated for the treatment of a variety of disorders including tumors, Alzheimer's and Parkinson's diseases, anti-inflammatory drugs, and analgesic agents.

MLCK inhibitor peptide 18 acetate is a selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.

1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(pyridin-4-yl)urea is a useful organic compound for research related to life sciences. The catalog number is T67700 and the CAS number is 1144075-47-7.

AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 μM AITC in a concentration-dependent manner (IC50= 10.3 μM).

USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.

C-Type Natriuretic Peptide (CNP) (1-22), human, is the 1-22 fragment of the parent C-Type Natriuretic Peptide.

Complement factor D-IN-1 is a potent and selective small-molecule reversible Factor D inhibitor, with IC50 values of 0.006 μM in the FD Thioesterolytic Fluorescent Assay and 0.05 μM in the MAC Deposition Assay.

c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer.

(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside ((-)-Syringaresnol-4-O-beta-D-apiofuranos) is a lignan glycoside derived from the bark of Albizzia myriophylla.

C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) is a potential inducer of myeloid differentiation via upregulation of C/EBP.

Genipin 1-β-D-gentiobioside is a natural product for research related to life sciences. The catalog number is T4S2299 and the CAS number is 29307-60-6.

ML-18 is a non-peptide bombesin receptor subtype-3 (BRS-3) antagonist with an IC50 of 4.8 [mu]M.

Adrenocorticotropic Hormone (ACTH) (18-39), human TFA (CLIP human TFA) is a corticotropin-like intermediate lobe peptide produced in the melanotrophs of the pituitary's intermediate lobe.

RN-18 is an inhibitor of HIV-1 viral infectivity factor (IC50: 6 μM in nonpermissive H9 cells).

1. Emodin-1-O-β-D-glucopyranoside (Emodin-1-O-glucoside) has neuroprotective and uncoupling activities, and that it may be the a new uncoupler of nNOS-PSD-95. 2. Emodin-1-O-β-D-glucopyranoside shows inhibitory effects on various tumor cells proliferation.

S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.

c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).

Hederagenin 28-O-{β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester}3-O-{α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl} is a saponin known for its antitumor and anti-inflammatory properties [1].

1-(3',5'-dimethoxy)phenyl-2-[4''-O-β-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane showed cytotoxic activities to Hela and hep2 cell lines.

E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioid receptor (KOR) agonist [1].

Benzyl [5-O-benzoyl-β-D-apiofuranosyl(1→2)]-β-D-glucopyranoside is a natural product for research related to life sciences. The catalog number is TN5741 and the CAS number is 1097040-08-8.

Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside exhibits antioxidant activity.

SMAP-18, an 18-amino acid residue peptide amide, is a biologically active truncated variant of Sheep myeloid antimicrobial peptide-29 (SMAP-29). It retains potent antimicrobial activity against Pseudomonas strains, other Gram-negative bacteria, and multidrug-resistant pathogens. Notably, SMAP-18 exhibits increased cell selectivity relative to the parent peptide SMAP-29 due to its reduced hemolytic activity while maintaining its antimicrobial efficacy.

1-(Piperidin-4-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one is a useful organic compound for research related to life sciences and the catalog number is T66378.

C-Met-IN-18, an ATP-competitive type-III inhibitor, targets both wild-type (WT) and D1228V mutant c-MET with IC50 values of 0.013 µM and 0.20 µM, respectively. It is utilized in research pertaining to c-MET-driven cancers [1].

VEGFR-2 c-Met-IN-1 is a dual inhibitor of VEGFR-2 and c-Met, with IC50 values of 138 nM and 74 nM, respectively, demonstrating antitumor activity [1].

C-Peptide 1 (rat), a β-catenin GSK-3β activator and regulator of the Wnt β-catenin signaling pathway, is utilized in cancer research [1].

Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C (GLS1).

c-Kit-IN-3 D-tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65490 and the CAS number is 170791-09-0.