camps-sp, triethylammonium

Rp-cAMPS competitively inhibits the cAMP-induced activation of cAMP-dependent protein kinase (PKA).

Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 µM and 9.75 µM, respectively.

Sp-cAMPS triethylamine, a cAMP analog, serves as a potent activator of cAMP-dependent PKA I and II, and acts as a competitive inhibitor of phosphodiesterase (PDE3A) with a K i of 47.6 µM. Additionally, it binds the PDE10 GAF domain with an EC 50 of 40 μM [1] [2] [3].

Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.

Rp-cAMPS TEA salt is a cAMP-dependent protein kinase (PKA) activator.

Sp-2-Cl-cAMPS serves as an agonist for PKA, boasting enhanced membrane permeability and stability against phosphodiesterases. This compound exhibits antimalarial activity, inhibiting the proliferation of the malaria parasite Plasmodium falciparum with an EC50 of 4 µM. Furthermore, Sp-2-Cl-cAMPS binds to the purified regulatory subunit of PfPKA (PfPKAr) with a Ki of 1.3 µM.

Sp-cAMPS-AM is an analog of cAMP that functions by penetrating cells and liberating its parent polar structure, Sp-cAMPS, thereby inducing PKA activation and CREB phosphorylation.

Sp-6-Phe-cAMPS is an effective activator of cAMP-dependent protein kinase (PKA) with site selectivity and membrane permeability. It does not activate the exchange factors directly stimulated by cAMP, making it suitable as a negative control for Epac. Sp-6-Phe-cAMPS can also be utilized in research on neurodegenerative diseases.

Sp-8-Br-cAMPS, an analog of cAMP, acts as an agonist for activating protein kinase A (PKA) with an EC50 of 360 nM. It inhibits T-cell proliferation and non-self responses in the hematocytes of Lepidopteran larvae.